KCNIP4 and IL17A

Data Source:
BioGRID (two hybrid)

		KCNIP4	IL17A
Description		potassium voltage-gated channel interacting protein 4	interleukin 17A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex	Extracellular Region Extracellular Space External Side Of Plasma Membrane
	Molecular Function	Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity	Cytokine Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Cardiac Conduction Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Positive Regulation Of Antimicrobial Peptide Production Adaptive Immune Response Apoptotic Process Inflammatory Response Immune Response Cell-cell Signaling Cell Death Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-16 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Intestinal Epithelial Structure Maintenance Cellular Response To Interleukin-1 Fibroblast Activation Interleukin-17-mediated Signaling Pathway Granulocyte Migration Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Pathways		Phase 1 - inactivation of fast Na+ channels	Interleukin-17 signaling Interleukin-4 and Interleukin-13 signaling
Drugs			Secukinumab Ixekizumab
Diseases
GWAS		Cadmium levels ( 26025379) Colorectal cancer ( 29228715) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 26169577) Diverticular disease ( 30177863) Lingual gyrus volume ( 31530798) Obesity-related traits ( 23251661) Parkinson disease and lewy body pathology ( 25663231) Post bronchodilator FEV1/FVC ratio ( 26634245) Postburn scar height ( 30595539) Rheumatoid arthritis ( 21156761) Suicidal ideation ( 20877300)	Height ( 28552196)
Interacting Genes		11 interacting genes: APP ASPH COL1A2 GOLGA7 IL17A KCND2 LITAF MEOX2 PSEN1 PSEN2 TRH	3 interacting genes: DPH2 IL17RA KCNIP4
Entrez ID		80333	3605
HPRD ID		12184	04396
Ensembl ID		ENSG00000185774	ENSG00000112115
Uniprot IDs		A8K4N3 Q6PIL6	Q16552
PDB IDs			2VXS 4HR9 4HSA 4QHU 5HHV 5HHX 5HI3 5HI4 5HI5 5N7W 5N92 5NAN 5VB9 6WIO 6WIR
Enriched GO Terms of Interacting Partners?
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