TNIP2 and MKNK1

Data Source:
BioGRID (two hybrid)

		TNIP2	MKNK1
Description		TNFAIP3 interacting protein 2	MAPK interacting serine/threonine kinase 1
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GO Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Kinase Binding Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Apoptotic Process Inflammatory Response Protein Deubiquitination CD40 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of B Cell Activation Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Endothelial Cell Apoptotic Process	Regulation Of Translation Protein Phosphorylation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation
Pathways		MAP3K8 (TPL2)-dependent MAPK1/3 activation Ovarian tumor domain proteases	Spry regulation of FGF signaling
Drugs			Fostamatinib
Diseases
GWAS		Extrinsic epigenetic age acceleration ( 29374233) Multiple sclerosis ( 31604244) Systemic lupus erythematosus ( 33536424)	Schizophrenia ( 26198764) Triglyceride levels ( 31170924)
Interacting Genes		24 interacting genes: APP CDKN1A CLK1 EP300 FBXO25 FLNA IKBKG MAP3K8 MAPK1 MKNK1 NCOR2 NFKB1 NFKB2 PSMD9 REL RELA SMARCD1 SMURF1 SRPK2 STK11 TEK TNFAIP3 TSG101 UBC	26 interacting genes: APP ATXN3 CREBBP CREM DDAH2 DNAJC7 EIF4E EIF4G1 EIF4G2 EIF4G3 FANCA HGS HIPK2 HSP90AB1 MAPK1 MAPK14 MAPK3 MBP PAK2 PHAX PLA2G4A PRKDC RCN3 SPRY2 TNIP2 UBE2D1
Entrez ID		79155	8569
HPRD ID		18207	09468
Ensembl ID		ENSG00000168884	ENSG00000079277
Uniprot IDs		D6RGJ2 Q8NFZ5	A8K341 Q7Z319 Q9BUB5
PDB IDs		5H07	2HW6 2Y9Q 5WVD
Enriched GO Terms of Interacting Partners?
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