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WIPF1 and PRKCQ
Data Source:
HPRD
(in vitro)
WIPF1
PRKCQ
Description
WAS/WASL interacting protein family member 1
protein kinase C theta
Image
GO Annotations
Cellular Component
Ruffle
Cytosol
Actin Filament
Actin Cytoskeleton
Cytoplasmic Vesicle
Immunological Synapse
Cytosol
Plasma Membrane
Aggresome
Centriolar Satellite
Molecular Function
Actin Binding
Protein Binding
Profilin Binding
SH3 Domain Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Calcium-dependent Protein Kinase C Activity
Protein Binding
ATP Binding
Metal Ion Binding
Biological Process
Actin Polymerization Or Depolymerization
Actin Filament-based Movement
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Response To Other Organism
Protein-containing Complex Assembly
Regulation Of Cell Growth
Regulation Of Transcription, DNA-templated
Membrane Protein Ectodomain Proteolysis
Inflammatory Response
Axon Guidance
Peptidyl-serine Phosphorylation
Platelet Activation
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-4 Production
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of T Cell Proliferation
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Insulin Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Telomerase Activity
Cell Chemotaxis
Negative Regulation Of T Cell Apoptotic Process
Regulation Of Platelet Aggregation
Positive Regulation Of Telomere Capping
Positive Regulation Of T-helper 17 Type Immune Response
Positive Regulation Of T-helper 2 Cell Activation
Pathways
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Apoptotic cleavage of cellular proteins
Effects of PIP2 hydrolysis
Downstream TCR signaling
Inactivation, recovery and regulation of the phototransduction cascade
FCERI mediated NF-kB activation
FCERI mediated NF-kB activation
Netrin-1 signaling
G alpha (z) signalling events
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RAS processing
Drugs
Tamoxifen
Staurosporine
Phosphonothreonine
Dexfosfoserine
Fostamatinib
Diseases
Type I diabetes mellitus
GWAS
Atrial fibrillation (
30061737
29892015
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
)
Pulse pressure (
27841878
)
Resting heart rate (
27798624
)
Systolic blood pressure (
27841878
)
Urate levels (BMI interaction) (
25811787
)
Asthma (
31959851
30929738
)
Asthma (bronchodilator response) (
23508266
)
Asthma (childhood onset) (
31036433
30929738
)
Autoimmune traits (pleiotropy) (
30572963
)
Body mass index in asthmatics (
23517042
)
Celiac disease (
22057235
24999842
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
)
Factor VII activity (
30642921
)
Immune response to smallpox vaccine (IL-6) (
22542470
)
Medication use (thyroid preparations) (
31015401
)
Rheumatoid arthritis (
30423114
18794853
24390342
20453842
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Type 1 diabetes (
19430480
18978792
)
Interacting Genes
26 interacting genes:
ABI2
ACTC1
ACTG1
ALAS1
APBB1
CACNG2
CDC42
CRKL
CTTN
FASTK
GRB2
HCK
HOMER3
ITSN2
NCK1
NCK2
PRKCQ
PRPF40A
RER1
SEC24C
SH3RF1
WAS
WASL
WBP4
WWP2
ZAP70
27 interacting genes:
AKT1
BTK
CARD11
CASP3
CBL
CHUK
CISH
FYN
GLRX3
GRM5
HABP4
ICAM3
IKBKB
IKBKG
IRS1
LCK
LYN
MARK3
MSN
RASGRP3
SELL
STK39
TAL1
VAV1
WIPF1
YWHAG
YWHAQ
Entrez ID
7456
5588
HPRD ID
03835
02710
Ensembl ID
ENSG00000115935
ENSG00000065675
Uniprot IDs
A0A140VJZ9
O43516
Q2YDC4
Q04759
PDB IDs
2A41
1XJD
2ENJ
2ENN
2ENZ
2JED
4Q9Z
4RA5
5F9E
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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