C1QB and PTX3

Data Source:
HPRD (in vitro)

		C1QB	PTX3
Description		complement C1q B chain	pentraxin 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Synapse Collagen-containing Extracellular Matrix Blood Microparticle Postsynapse	Extracellular Region Extracellular Space Extracellular Matrix Specific Granule Lumen Tertiary Granule Lumen
	Molecular Function	Protein Binding	Complement Component C1q Complex Binding (1->3)-beta-D-glucan Binding Protein Binding Identical Protein Binding Virion Binding
	Biological Process	Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response Synapse Pruning	Ovarian Cumulus Expansion Response To Yeast Inflammatory Response Opsonization Extracellular Matrix Organization Neutrophil Degranulation Negative Regulation By Host Of Viral Process Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Phagocytosis Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Neutrophil degranulation
Drugs		Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS			Body mass index ( 26426971)
Interacting Genes		11 interacting genes: C1QA C1QC C1R DEFA1 EDA2R HRG IL32 MYOC PTX3 RELA UBQLN2	15 interacting genes: C1QA C1QB C1QC CFH FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF5 FGF7 FGF8 MTNR1A
Entrez ID		713	5806
HPRD ID		00394	03928
Ensembl ID		ENSG00000173369	ENSG00000163661
Uniprot IDs		A0A024RAB9 P02746	P26022
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V
Enriched GO Terms of Interacting Partners?
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