PJA1 and PIP4K2C

Data Source:
BioGRID (enzymatic study)

		PJA1	PIP4K2C
Description		praja ring finger ubiquitin ligase 1	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
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GO Annotations	Cellular Component	Cytoplasm	Nucleoplasm Autophagosome Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Organelle Extracellular Exosome
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Identical Protein Binding
	Biological Process	Protein Ubiquitination Protein Catabolic Process	Phosphatidylinositol Biosynthetic Process Regulation Of Autophagy Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphorylation Negative Regulation Of 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus
Drugs			Fostamatinib
Diseases
GWAS		Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)	Rheumatoid arthritis ( 18794853)
Interacting Genes		64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3A GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440	4 interacting genes: APP BTK FBXO25 PJA1
Entrez ID		64219	79837
HPRD ID		02335	15138
Ensembl ID		ENSG00000181191	ENSG00000166908
Uniprot IDs		Q8NG27	B3KQV3 Q8TBX8
PDB IDs		2L0B	2GK9
Enriched GO Terms of Interacting Partners?
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