RYR1 and HOMER2

Data Source:
HPRD (in vivo, in vitro)

		RYR1	HOMER2
Description		ryanodine receptor 1	homer scaffold protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Smooth Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Junctional Sarcoplasmic Reticulum Membrane Terminal Cisterna Sarcoplasmic Reticulum Z Disc Cytoplasmic Vesicle Membrane Integral Component Of Organelle Membrane I Band Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma Extracellular Exosome Ryanodine Receptor Complex	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Dendrite Stereocilium Tip Neuronal Cell Body Intracellular Organelle Apical Part Of Cell Glutamatergic Synapse
	Molecular Function	Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Calcium-release Channel Activity Calcium-induced Calcium Release Activity	Actin Binding Protein Binding Protein Domain Specific Binding Synaptic Receptor Adaptor Activity G Protein-coupled Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Response To Hypoxia Outflow Tract Morphogenesis Calcium Ion Transport Muscle Contraction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Caffeine Ion Transmembrane Transport Skin Development Ossification Involved In Bone Maturation Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Calcium Ion Cellular Response To Caffeine Regulation Of Cardiac Conduction	G Protein-coupled Glutamate Receptor Signaling Pathway Sensory Perception Of Sound Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Calcium-mediated Signaling Using Intracellular Calcium Source Behavioral Response To Cocaine Chemical Homeostasis Within A Tissue Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry
Pathways		Stimuli-sensing channels Ion homeostasis	Neurexins and neuroligins Neurexins and neuroligins
Drugs		Caffeine Dantrolene Suramin Tetracaine
Diseases		Central core disease
GWAS		Abstraction and mental flexibility ( 31596458) Appendicular lean mass ( 33097823) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Diisocyanate-induced asthma ( 25918132) Peanut allergy (parent-of-origin effect) ( 29489655) White blood cell count (basophil) ( 27863252)	Tourette syndrome ( 30818990)
Interacting Genes		19 interacting genes: AKAP6 ANK1 CACNA1S CALM1 CAMK2G CAV3 FKBP1A HOMER1 HOMER2 HOMER3 MTDH PDLIM3 PRKACA PRKG1 RYR2 S100A1 TRDN TTN TULP3	14 interacting genes: ABI3 AGAP2 APP DBN1 GRM1 ITPR1 KPNA2 LZTS2 PALLD PJA1 RYR1 SMURF1 UBXN1 VKORC1
Entrez ID		6261	9455
HPRD ID		01618	07269
Ensembl ID		ENSG00000196218	ENSG00000103942
Uniprot IDs		P21817	Q9NSB8
PDB IDs		6UHI 6UHS
Enriched GO Terms of Interacting Partners?
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