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PRKCI and PARD6B
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
PRKCI
PARD6B
Description
protein kinase C iota
par-6 family cell polarity regulator beta
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Nucleoplasm
Endosome
Cytosol
Plasma Membrane
Bicellular Tight Junction
Microtubule Cytoskeleton
Apical Plasma Membrane
Cell Leading Edge
Schmidt-Lanterman Incisure
Intercellular Bridge
Extracellular Exosome
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Nucleus
Cytosol
Plasma Membrane
Bicellular Tight Junction
Cell Cortex
Apical Plasma Membrane
Protein-containing Complex
Extracellular Exosome
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Protein Binding
ATP Binding
Phospholipid Binding
Metal Ion Binding
Protein Kinase C Binding
Protein Binding
Biological Process
Protein Phosphorylation
Protein Targeting To Membrane
Cytoskeleton Organization
Actin Filament Organization
Positive Regulation Of Neuron Projection Development
Vesicle-mediated Transport
Cell Migration
Peptidyl-serine Phosphorylation
Cellular Response To Insulin Stimulus
Negative Regulation Of Glial Cell Apoptotic Process
Establishment Of Apical/basal Cell Polarity
Intracellular Signal Transduction
Eye Photoreceptor Cell Development
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Cell-cell Junction Organization
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Glucose Import
Secretion
Golgi Vesicle Budding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Glial Cell Proliferation
Membrane Organization
Response To Interleukin-1
Bicellular Tight Junction Assembly
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Endothelial Cell Apoptotic Process
Cell-cell Junction Assembly
Centrosome Cycle
Establishment Or Maintenance Of Cell Polarity
Axonogenesis
Regulation Of Cell Migration
Cell Division
Regulation Of Cellular Localization
Protein-containing Complex Assembly
Bicellular Tight Junction Assembly
Pathways
Pre-NOTCH Transcription and Translation
p75NTR recruits signalling complexes
Tight junction interactions
Tight junction interactions
Drugs
Tamoxifen
Bisindolylmaleimide I
Fostamatinib
Diseases
GWAS
Microalbuminuria (
31511532
)
Prostate cancer (
25939597
)
Urinary albumin excretion (
30220432
)
Urinary albumin-to-creatinine ratio (
31630189
31511532
)
Bipolar disorder (
21771265
)
Interacting Genes
52 interacting genes:
ADAP1
ANXA1
APP
BAD
CASK
CASP8
CCNT1
CDC42
CDK7
CHUK
CTBP1
FABP4
FCGR3A
FRS2
FRS3
GAPDH
HRAS
IKBKG
IL1RAP
IRAK1
MAP2K1
MAP2K5
MAPT
MARK4
MBP
MEOX2
NACC1
NFKBIA
PARD3
PARD6A
PARD6B
PARD6G
PCM1
PDPK1
PNMA1
RAB2A
RAB4A
RAC1
RBM14
RHOQ
RPA2
SMG1
SMURF1
SQSTM1
SRC
TSC22D1
TTR
UBC
USP20
VHL
YWHAH
YWHAZ
33 interacting genes:
APP
ARAP3
BANP
CDC42
CDCA4
CEP76
FRMD6
GMCL1
GOLGA2
HSF2BP
HTRA1
MAGOHB
PALS1
PARD3
PARD3B
PARD6A
PNMA1
PRKCG
PRKCI
PRKCZ
RAC1
RASSF3
RHOJ
RHOQ
SIAH1
TCP10L3
TRIB3
TRIM35
WDR83
YWHAB
YWHAH
YWHAZ
ZSCAN4
Entrez ID
5584
84612
HPRD ID
02105
18703
Ensembl ID
ENSG00000163558
ENSG00000124171
Uniprot IDs
P41743
Q9BYG5
PDB IDs
1VD2
1WMH
1ZRZ
3A8W
3A8X
3ZH8
5LI1
5LI9
5LIH
6ILZ
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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