STAP2 and TXK

Data Source:
BioGRID (two hybrid)

		STAP2	TXK
Description		signal transducing adaptor family member 2	TXK tyrosine kinase
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	Protein Binding Signaling Adaptor Activity	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein	Cytokine Production Adaptive Immune Response Protein Phosphorylation Activation Of Phospholipase C Activity Integrin-mediated Signaling Pathway Regulation Of Gene Expression Regulation Of Platelet Activation Positive Regulation Of Interferon-gamma Production Peptidyl-tyrosine Autophosphorylation Tissue Regeneration Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways		PTK6 Activates STAT3	FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs			Fostamatinib Zanubrutinib
Diseases
GWAS		Tea consumption ( 31046077)	Crohn's disease ( 23128233) Mean platelet volume ( 32888494) Multiple sclerosis ( 31604244) Platelet distribution width ( 32888494 27863252)
Interacting Genes		18 interacting genes: BLK BMP4 CBL CHUK CSF1R EGFR IKBKB JAK2 KEAP1 MLH1 MYD88 PTK6 SRC STAT3 STAT5A STAT5B TXK YES1	38 interacting genes: CBY2 CCDC33 CCR5 CLNK CRK CTLA4 DOK2 DUSP6 EFHC2 EGFR ERBB2 ERBB3 ERBB4 FYN GRB10 GRB2 HOMEZ IKZF1 IKZF4 JRK KIT LCP2 MET NCK2 NELFCD PIK3R1 PRDM14 RBAK SH2D2A SOCS3 SOCS6 SRC STAP2 TNS4 YTHDC1 ZNF587 ZNF792 ZNF835
Entrez ID		55620	7294
HPRD ID		07430	02505
Ensembl ID		ENSG00000178078	ENSG00000074966
Uniprot IDs		Q9UGK3	P42681
PDB IDs		2EL8	2DM0
Enriched GO Terms of Interacting Partners?
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