PLN and FAM209A

Data Source:
BioGRID (two hybrid)

		PLN	FAM209A
Description		phospholamban	family with sequence similarity 209 member A
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Mitochondrial Membrane Vesicle Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Calcium Ion-transporting ATPase Complex	Nucleus Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Enzyme Inhibitor Activity Protein Binding ATPase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity ATPase Binding	Molecular_function Protein Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Calcium Ion Transport Notch Signaling Pathway Blood Circulation Regulation Of Heart Contraction Response To Zinc Ion Negative Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of ATPase Activity Response To Insulin Response To Testosterone Negative Regulation Of Catalytic Activity Cardiac Muscle Tissue Development Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Relaxation Of Cardiac Muscle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Negative Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Binding Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum	Biological_process
Pathways		Ion homeostasis Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818 30061737) Cardiac structure and function ( 19584346) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 27577874 27659466) QT interval ( 23166209 24952745 19305408 19305409 19587794 29874175) Resting heart rate ( 27798624)	Heschl's gyrus morphology ( 25130324)
Interacting Genes		64 interacting genes: ARL13B ASGR2 ATP2A1 ATP2A2 ATP6V0E1 BCL2L13 BIK CD53 CLDN7 CLEC2D CPLX4 CREB3 CREB3L1 DMPK DVL3 EDA ELOVL4 FAM209A FKBP8 FNDC9 GJA8 GPR152 GPR37L1 GPX8 HIBADH HSD17B13 KIR2DL3 LDLRAD1 LSMEM2 MFF MFSD5 MGST2 MGST3 MS4A7 MTIF3 MUC1 PLPPR1 PPP1R3A PRKACA RTN3 S100A1 SAR1A SDC3 SIT1 SLC14A2 SLC30A8 SLC34A2 SLC35C2 SLC39A2 SLN SPACA1 SPAG4 STX1A STX2 TMEM106C TMEM179B TMEM205 TMEM31 TMEM45A TMEM45B TMEM52B TMEM79 TMEM86B TMPRSS2	231 interacting genes: - ADGRE2 ADIPOQ AGTRAP AIG1 ALG8 ANKRD46 APMAP APOC3 APOD APOL2 AQP1 AQP2 AQP3 ARV1 ASGR1 ATP13A1 B4GALNT2 BDNF BET1 BIK BMP10 BNIP2 BNIP3 BTN2A2 C11orf24 C14orf180 C1GALT1 C2 C3orf52 C4orf3 CANT1 CCL4L2 CD53 CD59 CD81 CDIPT CDS1 CDS2 CLCA4 CLDN19 CLDN2 CLDN4 CLDND2 CLEC4G CLN6 CMTM7 CNIH1 CNPY3 COL4A5 COL8A2 COMT CTRL CTSA CTXN3 CXCL16 CYB561D2 CYB5B CYBC1 DEFB121 DEFB128 DNAJC30 DOLK EBP EMC6 EMD ENTPD3 EOGT ERG28 ERMP1 FA2H FAM20B FAM3C FATE1 FCER1G FDFT1 FIS1 FXYD3 GAST GET3 GHITM GIMAP1 GJB2 GKN1 GKN2 GOSR2 GPR108 GPR151 GPR37L1 GYPA HACD2 HHATL HMOX1 HMOX2 HTATIP2 IGFBP5 INSIG2 JAGN1 KIR2DL3 LHFPL5 LPAR3 LRP10 MAL MARCHF2 MFF MGLL MIP MMD MMD2 MS4A1 MS4A13 MYADM MYADML2 NAPB NAT8 NCR3 NINJ2 NRM NXPE3 OLFM4 ORMDL3 OTOR PAQR7 PEDS1-UBE2V1 PGAP2 PGLYRP3 PLN PLP1 PLP2 PLPP4 PLPP6 PMP22 PNLIPRP1 PRB1 PTCH1 RHAG RPRM RTP2 RUSF1 S100A2 SCARF1 SCGB1D1 SCRG1 SEC22A SEC22B SEC61G SELENOK SEMA6C SERP1 SFTPC SLC13A3 SLC1A1 SLC30A8 SLC35A1 SLC35A4 SLC35B4 SLC35E3 SLC35G2 SLC38A7 SLC52A2 SLC7A14 SMCO4 SMIM1 SNORC STATH STX1B STX3 STX5 STX8 SYNGR1 SYT15 TECR TEX264 TFRC THBD THSD7B TM6SF2 TMBIM6 TMEM100 TMEM107 TMEM11 TMEM120A TMEM128 TMEM140 TMEM141 TMEM14B TMEM14C TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM236 TMEM243 TMEM254 TMEM42 TMEM43 TMEM47 TMEM50B TMEM60 TMEM65 TMEM72 TMEM79 TMEM86A TMEM86B TMEM97 TMPRSS4 TMUB2 TNF TNFRSF10C TNMD TRAF3IP3 TRAM1L1 TSPAN2 TSPAN33 TSPAN7 TSPO TWSG1 UBE2J1 UBIAD1 UNC50 UPK1B VAMP3 VAMP4 VAMP5 VKORC1 VMP1 WFDC2 WFS1 YIPF6 ZFPL1
Entrez ID		5350	200232
HPRD ID		01395	18536
Ensembl ID		ENSG00000198523	ENSG00000124103
Uniprot IDs		P26678 Q5R352	Q5JX71
PDB IDs		1K9N 1KCH 1PLN 1PLP 1PSL 1ZLL 2HYN
Enriched GO Terms of Interacting Partners?
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