PLAC8 and LCE1C

Data Source:
BioGRID (two hybrid)

		PLAC8	LCE1C
Description		placenta associated 8	late cornified envelope 1C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Azurophil Granule Lumen
	Molecular Function	Chromatin Binding	Protein Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation Response To Cold Negative Regulation Of Multicellular Organism Growth Defense Response To Bacterium Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of Transcription By RNA Polymerase II Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis	Keratinization
Pathways		Neutrophil degranulation	Formation of the cornified envelope
Drugs
Diseases
GWAS		QRS interval (sulfonylurea treatment interaction) ( 27958378)	Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		24 interacting genes: BAG4 C19orf54 COPS5 CYSRT1 FCHO1 KRTAP12-2 KRTAP19-1 KRTAP19-6 LCE1A LCE1C LCE2B LCE5A MEOX2 PLAGL2 PPP3CA RBPMS RHOXF2 TEX37 TRAF1 TRIP13 UBAP2 USP54 VAMP5 WWOX	67 interacting genes: ADAMTSL4 CHIC2 CHRD CRCT1 CREB5 CYSRT1 EFEMP1 EFEMP2 FBLN1 GUCD1 HOXA1 KRTAP10-1 KRTAP10-5 KRTAP10-8 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-3 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE4A LCE5A MACO1 NECTIN2 NTAQ1 NTN4 NUTF2 ODF1 OIT3 OTX1 PLA2G10 PLAC8 PLSCR3 PLSCR4 POU4F2 PSMB1 SLC39A7 SPRED2 SPRY1 SPRY2 TGFB1 TRIM42 VASN VWC2 VWC2L
Entrez ID		51316	353133
HPRD ID		06335	13967
Ensembl ID		ENSG00000145287	ENSG00000197084
Uniprot IDs		Q9NZF1 X2BQ60	Q5T751
PDB IDs
Enriched GO Terms of Interacting Partners?
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