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PRDX1 and SESN2
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
PRDX1
SESN2
Description
peroxiredoxin 1
sestrin 2
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Melanosome
Extracellular Exosome
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Nucleotide-activated Protein Kinase Complex
TORC2 Complex
GATOR2 Complex
Atg1/ULK1 Kinase Complex
Molecular Function
RNA Binding
Peroxidase Activity
Protein Binding
Thioredoxin Peroxidase Activity
Cadherin Binding
GDP-dissociation Inhibitor Activity
Protein Binding
Oxidoreductase Activity, Acting On Peroxide As Acceptor
Sulfiredoxin Activity
Leucine Binding
Biological Process
Skeletal System Development
Retina Homeostasis
Response To Oxidative Stress
Cell Population Proliferation
Removal Of Superoxide Radicals
Natural Killer Cell Activation
Cellular Response To Stress
Cellular Response To Oxidative Stress
Hydrogen Peroxide Catabolic Process
Leukocyte Activation
Cell Redox Homeostasis
Regulation Of Protein Phosphorylation
Regulation Of Gluconeogenesis
Fatty Acid Beta-oxidation
Response To Glucose
Positive Regulation Of Macroautophagy
Negative Regulation Of Cell Growth
DNA Damage Response, Signal Transduction By P53 Class Mediator
Mitochondrial DNA Metabolic Process
Response To Insulin
Cellular Response To Amino Acid Starvation
Cellular Response To Oxidative Stress
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Cellular Response To Glucose Starvation
Glucose Homeostasis
Protein Kinase B Signaling
Glucose Import
Triglyceride Homeostasis
Cellular Response To Amino Acid Stimulus
Cellular Response To Leucine
Reactive Oxygen Species Metabolic Process
Cellular Oxidant Detoxification
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Response To Reactive Oxygen Species
Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress
Negative Regulation Of TORC1 Signaling
Positive Regulation Of Lipophagy
Cellular Response To Leucine Starvation
Regulation Of CAMP-dependent Protein Kinase Activity
Pathways
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
TP53 Regulates Metabolic Genes
Amino acids regulate mTORC1
Drugs
Zinc
Copper
Artenimol
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Blood protein levels (
28240269
)
Body mass index (
26426971
)
Hemoglobin (
32888494
)
Serum uric acid levels (
30993211
)
Urate levels (
31578528
)
Interacting Genes
29 interacting genes:
ABL1
ADH5
ADRB2
AXIN2
BTRC
CALM1
CCR4
CLEC4G
EGFR
GAPDH
IRF3
LUC7L
MTRNR2L1
MYC
MYD88
PPP2R1A
PPP2R1B
PRDX4
PTEN
PTGER4
SESN1
SESN2
SH2D1B
SMARCD1
SNCA
TERF1
UBE3A
VHL
YWHAQ
3 interacting genes:
MDM2
PRDX1
RNF186
Entrez ID
5052
83667
HPRD ID
01458
06378
Ensembl ID
ENSG00000117450
ENSG00000130766
Uniprot IDs
A0A384NPQ2
Q06830
P58004
PDB IDs
2RII
3HY2
4XCS
5CUF
5DJ4
5T0N
6N0M
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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