ORC2 and CDT1

Data Source:
HPRD (in vitro)

		ORC2	CDT1
Description		origin recognition complex subunit 2	chromatin licensing and DNA replication factor 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Heterochromatin Origin Recognition Complex Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane	Kinetochore Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytosol Nuclear Body
	Molecular Function	DNA Replication Origin Binding Protein Binding	DNA Binding Chromatin Binding Protein Binding DNA Polymerase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Replication Initiation	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Chromosome Segregation Regulation Of DNA-dependent DNA Replication Initiation Positive Regulation Of Protein-containing Complex Assembly Regulation Of Chromosome Organization Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Positive Regulation Of DNA Replication Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization DNA Replication Preinitiation Complex Assembly Response To Sorbitol Deactivation Of Mitotic Spindle Assembly Checkpoint Regulation Of DNA Replication Origin Binding Negative Regulation Of Protein Localization To Kinetochore Positive Regulation Of Protein Localization To Kinetochore Positive Regulation Of DNA-dependent DNA Replication
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases			Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)	Glycated hemoglobin levels ( 28898252) Hair color ( 26926045) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010 20139978 28017375) Mean corpuscular volume ( 29403010)
Interacting Genes		28 interacting genes: CDC45 CDC5L CDC6 CDK2 CDT1 CTNNA3 DBF4 EP300 H3-4 H4-16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RAD18 RIPPLY3 RPA1 RPA2 XRCC5	28 interacting genes: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK14 MCM2 MCM4 MCM6 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB
Entrez ID		4999	81620
HPRD ID		03112	06900
Ensembl ID		ENSG00000115942	ENSG00000167513
Uniprot IDs		A0A024R411 Q13416	Q9H211
PDB IDs		5C8H 5UJ8 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS	2LE8 2WVR 6QCG
Enriched GO Terms of Interacting Partners?
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