MAP3K10 and KIF17

Data Source:
BioGRID (two hybrid)

		MAP3K10	KIF17
Description		mitogen-activated protein kinase kinase kinase 10	kinesin family member 17
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Microtubule Organizing Center Cytosol Kinesin Complex Microtubule Cilium Axoneme Photoreceptor Connecting Cilium Dendrite Cytoplasm Ciliary Basal Body Neuron Projection Periciliary Membrane Compartment
	Molecular Function	Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity ATP Binding Protein Homodimerization Activity BHLH Transcription Factor Binding	Microtubule Motor Activity ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity
	Biological Process	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Protein Autophosphorylation	Microtubule-based Movement Vesicle-mediated Transport Cell Projection Organization Intraciliary Transport Involved In Cilium Assembly Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex
Pathways			Intraflagellar transport Assembly and cell surface presentation of NMDA receptors
Drugs		Fostamatinib
Diseases
GWAS		Birth weight ( 31043758) Resting heart rate ( 27798624)	Ceramide levels (C24:0) ( 32489964) Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		31 interacting genes: ABL2 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS1 HGS HTT KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP3K21 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB RAC1 RACGAP1 SH3RF1 SMURF1 TUBB YWHAE	7 interacting genes: APBA1 FHL5 GFI1B MAP3K10 MAP3K11 PHAF1 XPO1
Entrez ID		4294	57576
HPRD ID		02533	10388
Ensembl ID		ENSG00000130758	ENSG00000117245
Uniprot IDs		Q02779	A0A0A0MRS8 Q9P2E2
PDB IDs		2RF0
Enriched GO Terms of Interacting Partners?
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