MCM3 and CDC45

Data Source:
HPRD (two hybrid)

		MCM3	CDC45
Description		minichromosome maintenance complex component 3	cell division cycle 45
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Centrosome Membrane MCM Complex Perinuclear Region Of Cytoplasm CMG Complex	Nucleus Nucleoplasm Cytoplasm Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body
	Molecular Function	DNA Binding DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding Mitotic DNA Replication Initiation	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Mitotic DNA Replication Preinitiation Complex Assembly
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases
GWAS			Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		36 interacting genes: CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 EP300 HAUS1 KEAP1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 MCMBP ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B PTEN RAD52 STAT1 SUMO2 SUPT16H SYF2 TRIM28 YWHAQ	25 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1
Entrez ID		4172	8318
HPRD ID		04072	09145
Ensembl ID		ENSG00000112118	ENSG00000093009
Uniprot IDs		A0A0S2Z4T1 A0A499FHX9 B4DUQ9 P25205	O75419
PDB IDs		6XTX 6XTY	5DGO 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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