KIR2DL3 and LAT

Data Source:
BioGRID (two hybrid)

		KIR2DL3	LAT
Description		killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3	linker for activation of T cells
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Immunological Synapse Golgi Apparatus Plasma Membrane COP9 Signalosome Integral Component Of Membrane Membrane Raft
	Molecular Function	Antigen Binding Protein Binding Signaling Receptor Activity Identical Protein Binding	Protein Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Immune Response Regulation Of Immune Response	MAPK Cascade Adaptive Immune Response Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Regulation Of T Cell Activation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	GPVI-mediated activation cascade Generation of second messenger molecules
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)
Interacting Genes		64 interacting genes: ADGRE2 AGTRAP AIG1 ANKRD46 APOA2 APOD APP AQP10 ASGR1 ATP6V0E1 BMP10 BRICD5 BTN2A2 C3orf52 CDIPT CISD2 CLDN19 CLN6 COQ9 CXCL16 CXCL9 CYB5B CYBC1 EMD FAM209A FAM3C FUNDC2 GAST GJA8 GPR108 GPX8 HLA-C IFITM3 INSIG2 ITGAM JAGN1 KTN1 LAT LCK LEUTX LHFPL5 NINJ2 NRM NSG1 OLFM4 PLN PLPPR2 PTPN6 RNF152 RTP2 SEC22B SLC38A7 SMIM1 SNORC THBD TMEM218 TMEM222 TMEM243 TMEM86B TMEM97 TRAF3IP3 UPK1B UPK2 VAMP5	95 interacting genes: APH1A ASGR2 BCL2L13 BSCL2 CAMLG CBL CD244 CD3G CD4 CD53 CD8A CDIP1 CLDN2 CLDN5 CLDN7 CREB3 CXorf66 CYBC1 EGFR FCGR1A FCGR2A FFAR2 FFAR3 FKBP7 FYN GAB2 GJA8 GJB1 GJB3 GOLM1 GPR101 GPR151 GPR152 GPR42 GRAP GRAP2 GRB2 ITK JSRP1 KASH5 KCTD17 KIR2DL3 LCK LCP2 LEUTX LHFPL1 LHFPL5 LMNA MAP1LC3C MAP4K1 MEOX2 MFF MFSD14B MFSD5 MRPS18B MS4A7 MTIF3 NDUFAF2 OPRM1 PIK3R1 PLCG1 PLCG2 PRR4 PSCA PTPN1 PTPN6 PTPRJ SAR1A SERINC2 SGTA SGTB SH3BP2 SHB SLA SLC14A2 SLC16A2 SLC18A1 SLC19A3 SLC26A6 SLC35C2 SLC51B SLPI SSMEM1 SYK SYT2 THAP4 TM4SF18 TMEM237 TMEM45B TMEM80 TNFRSF10D VAV1 ZAP70 ZDHHC7 ZHX2
Entrez ID		3804	27040
HPRD ID		10383	03832
Ensembl ID		ENSG00000243772	ENSG00000213658
Uniprot IDs		E3NZD8 P43628	A0A024QZD6 O43561
PDB IDs		1B6U
Enriched GO Terms of Interacting Partners?
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