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ARAF and RRAS2
Data Source:
HPRD
(two hybrid)
ARAF
RRAS2
Description
A-Raf proto-oncogene, serine/threonine kinase
RAS related 2
Image
GO Annotations
Cellular Component
Cellular_component
Mitochondrion
Cytosol
Golgi Membrane
Endoplasmic Reticulum
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Exosome
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Cellular Protein Modification Process
Protein Phosphorylation
Regulation Of TOR Signaling
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Apoptotic Process
Osteoblast Differentiation
Ras Protein Signal Transduction
Positive Regulation Of Cell Migration
Regulation Of Neuron Death
Pathways
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by MRAS-complex mutants
Drugs
ATP
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Alzheimer's disease (cognitive decline) (
23535033
)
Apolipoprotein A1 levels (
32203549
)
Brain morphology (MOSTest) (
32665545
)
Height (
31562340
)
Mitochondrial DNA levels (
25240745
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Multiple sclerosis (
31604244
)
Refractive error (
32231278
)
Vitamin D levels (
25208829
)
Interacting Genes
59 interacting genes:
AGTRAP
AKT1
ASS1
BAD
BECN1
BRAF
CCND2
CDK4
CDK6
CDKN2B
CHD6
COPS3
CPS1
CSNK2B
DIDO1
E2F6
EFEMP1
EPHA2
FGFR4
GLIS2
GNA12
HRAS
IRAK2
IRF7
KLHL12
KRAS
LATS2
MAP2K1
MAP2K2
MAP2K3
MAP2K5
MLH1
MYC
MYO18A
NELFCD
NF2
NRAS
NUDT14
PBK
PDGFRB
PIK3CA
PIK3R1
PKM
PRPF6
RABGGTB
RASSF1
RGS12
RRAS
RRAS2
SFN
STK11
TEKT4P2
TESK1
TIMM44
TIRAP
TP53
TSC1
WNK1
YWHAG
32 interacting genes:
ACVR1
AFDN
AHSG
ARAF
ARHGEF2
BMPR1B
CREB3
FNTB
HDAC7
LGALS4
PAWR
PGGT1B
PIK3R1
PTPN1
RABAC1
RAF1
RALGDS
RAP1GDS1
RAPGEF1
RAPGEF3
RAPGEF4
RASGRF1
RASIP1
RASSF5
RGL3
RIN1
SMAD3
SMAD4
SMURF2
TRAF2
TRAF3
XRCC6
Entrez ID
369
22800
HPRD ID
02405
02518
Ensembl ID
ENSG00000078061
ENSG00000133818
Uniprot IDs
A0A024R178
P10398
Q96II5
P62070
PDB IDs
1WXM
2MSE
2ERY
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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