EPN1 and CEP126

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EPN1	CEP126
Description		epsin 1	centrosomal protein 126
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endosome Cytosol Plasma Membrane Clathrin-coated Pit Clathrin Vesicle Coat Intracellular Membrane-bounded Organelle	Cytoplasm Centrosome Midbody Ciliary Base
	Molecular Function	Protein Binding Phospholipid Binding Clathrin Binding	Protein Binding
	Biological Process	Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization Negative Regulation Of Sprouting Angiogenesis	Mitotic Spindle Organization Cytoplasmic Microtubule Organization Cilium Assembly Non-motile Cilium Assembly
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		1,4-Dioxane 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Major depressive disorder ( 23377640)
Interacting Genes		25 interacting genes: AP2A1 AP2A2 CDK1 CEP126 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 HIP1R LAPTM5 LITAF MAP3K1 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G SMURF1 TFAP2A UBC ZBTB16	87 interacting genes: AIMP2 AKTIP ARIH2 ATP6V1F ATRX BMI1 BRD1 C11orf58 CDKN2B CRCT1 CSTF2 DGCR6 DISC1 DLEU1 DNM1 DUSP12 DUSP23 EIF2S2 EIF6 EPN1 FAM118B FEZ1 FGFR3 FXR1 GEMIN7 GET4 GIT1 GOLGB1 GPRASP2 GSTO1 HMOX2 HTT ING5 KAT5 KAT7 KIF15 KLHL20 LAMTOR5 LPL LRRC1 LUC7L2 MAD2L1BP MAPK9 MLH1 MRPS6 NAP1L5 NAT9 NPM3 NSF NUDT21 ODF2L OFD1 PBK PDCD5 PFDN1 PIK3R3 PMF1 POLD1 POLR2M PPP1CA PPP1CC PRKRA PTPRS RAB27A RAN RBM23 RETREG2 RGS2 RIF1 ROGDI RPA2 RUVBL1 SAT1 SNRPG SPDL1 STAU2 TFG TNFRSF14 TNFSF11 TOMM20 TTR TXNDC9 VIM YAE1 YWHAZ ZBED8 ZNF24
Entrez ID		29924	57562
HPRD ID		06270	17212
Ensembl ID		ENSG00000063245	ENSG00000110318
Uniprot IDs		A0A024R4S1 Q9Y6I3	Q9P2H0
PDB IDs		1INZ 1KYD
Enriched GO Terms of Interacting Partners?
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