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BLNK and CD79A
Data Source:
HPRD
(in vivo, in vitro)
BLNK
CD79A
Description
B cell linker
CD79a molecule
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Cytoplasmic Ribonucleoprotein Granule
Multivesicular Body
Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
B Cell Receptor Complex
Membrane Raft
Molecular Function
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Protein Binding
Enzyme Binding
Signaling Adaptor Activity
SH2 Domain Binding
Protein Tyrosine Kinase Binding
Transmembrane Signaling Receptor Activity
Protein Binding
Identical Protein Binding
Biological Process
Inflammatory Response
Humoral Immune Response
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Gene Expression
B Cell Differentiation
Intracellular Signal Transduction
B Cell Receptor Signaling Pathway
Adaptive Immune Response
B Cell Differentiation
B Cell Proliferation
B Cell Activation
B Cell Receptor Signaling Pathway
Pathways
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
CD22 mediated BCR regulation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS
Mean spheric corpuscular volume (
32888494
)
Brain morphology (MOSTest) (
32665545
)
Interacting Genes
25 interacting genes:
AR
BTK
CBL
CBLB
CD72
CD79A
CMTM3
CRKL
EGFR
ERBB2
ERBB3
GAB1
GRAP2
GRB2
ITK
KIT
LCP2
MAP4K1
NCK1
PLCG1
PLCG2
PTPN6
SH3KBP1
SYK
VAV1
181 interacting genes:
ADIPOQ
AGTRAP
ALG10
ALG10B
ALG3
APOD
AQP1
AQP3
ATP6V0C
BCL2L2
BET1
BLK
BLNK
BRICD5
BTN2A2
C14orf180
C1GALT1
C2CD2L
C4orf3
CCDC167
CD19
CD5
CD79B
CDIPT
CLDN1
CLN6
CMTM5
CMTM7
CNIH1
CNIH3
COL4A5
CTSA
CTXN3
CYB561
CYB561A3
CYB561D2
CYB5B
DEFB127
DOLK
EDDM3B
EMC6
EMP1
EMP3
FA2H
FAM241B
FANCA
FATE1
FAXDC2
FCAR
FDFT1
FFAR3
FKBP8
FUNDC2
FXYD3
FYN
GALNT15
GIMAP1
GJB1
GPR42
HACD4
HCLS1
HMOX1
HMOX2
IER3
IGHM
INSIG2
ITGAM
JAGN1
JCHAIN
LAMB1
LCK
LEPROTL1
LHFPL5
LPAR3
LTC4S
LYN
MALL
MARCHF2
MFF
MFSD12
MFSD5
MFSD6
MGLL
MMD2
MOSPD3
MS4A13
MYADM
MYADML2
NAT8
NEU1
NINJ2
NIPAL3
NKG7
ORMDL2
OTOP2
PGAP2
PIGR
PKMYT1
PLP2
PLPP6
PLPPR2
PNLIPRP1
PRAF2
PTCH1
PTPN6
REEP6
RHO
RTP2
SACM1L
SEC22B
SERP1
SFTPC
SLC13A4
SLC13A5
SLC16A12
SLC16A13
SLC30A2
SLC35B1
SLC35B4
SLC38A1
SLC39A2
SLC39A9
SLC41A1
SLC41A2
SLC46A3
SLC66A2
SLC6A12
SLC7A1
SMCO4
SMIM3
STRIT1
STX12
STX3
STX8
SYK
SYNJ2BP
TECR
THBD
TM4SF19
TM4SF4
TMBIM6
TMEM107
TMEM11
TMEM128
TMEM140
TMEM147
TMEM14B
TMEM176A
TMEM187
TMEM19
TMEM218
TMEM222
TMEM229B
TMEM239
TMEM243
TMEM254
TMEM262
TMEM42
TMEM86A
TMEM86B
TMPPE
TNFRSF10C
TRAM1L1
TRARG1
TSNARE1
TSPAN2
TSPO2
UBE2J1
UBIAD1
UNC93B1
VAMP3
VAPA
VAPB
VTI1B
WFDC2
WFS1
YIF1A
YIPF4
YIPF6
ZDHHC15
ZDHHC22
Entrez ID
29760
973
HPRD ID
05153
00203
Ensembl ID
ENSG00000095585
ENSG00000105369
Uniprot IDs
Q2MD54
Q2MD59
Q8WV28
P11912
PDB IDs
1CV9
Enriched GO Terms of Interacting Partners
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