GLUL and NUDT18

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GLUL	NUDT18
Description		glutamate-ammonia ligase	nudix hydrolase 18
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Extracellular Exosome	Cytosol
	Molecular Function	Glutamate-ammonia Ligase Activity Protein Binding ATP Binding Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Metal Ion Binding	Magnesium Ion Binding Protein Binding 8-oxo-dGDP Phosphatase Activity 8-oxo-GDP Phosphatase Activity 8-hydroxy-dADP Phosphatase Activity
	Biological Process	Neurotransmitter Uptake Angiogenesis Glutamate Catabolic Process Glutamine Biosynthetic Process Cell Population Proliferation Cellular Amino Acid Biosynthetic Process Regulation Of Endothelial Cell Migration Protein Phosphopantetheinylation Protein Palmitoylation Ribosome Biogenesis Regulation Of Sprouting Angiogenesis Regulation Of Protein Localization To Nucleolus	Nucleobase-containing Small Molecule Catabolic Process DADP Catabolic Process DGDP Catabolic Process GDP Catabolic Process
Pathways		Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate and glutamine metabolism
Drugs		L-Glutamine Glutamic acid
Diseases		Congenital systemic glutamine deficiency (CSGD); Glutamine synthetase deficiency
GWAS		Cardiovascular heart disease in diabetics ( 23982368) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol levels ( 32203549) Morning person ( 30696823)
Interacting Genes		22 interacting genes: CASP8AP2 CRBN CYP39A1 DYNLL1 EP300 HIPK1 HIPK3 HSD17B10 HTR2A MT-ND5 NFKB1 NUDT18 PIAS1 PIAS2 PIAS3 PLEKHF2 PPARD RABEPK RBBP6 SKIL TAT UBE2I	34 interacting genes: APIP CAVIN2 COIL CUTC DCTD DHPS DUT EVI5L GLUL GNMT GSE1 HSD17B14 KCTD13 KCTD17 KHDRBS3 KRT15 KRTAP4-12 KXD1 NADK NAT9 NT5C2 PAICS PCBD1 PSME3 RAB3IL1 RABAC1 RAD54B RWDD1 TARBP2 TERF2IP TIFA TRAF2 TRIM37 ZBED1
Entrez ID		2752	79873
HPRD ID		00701	07992
Ensembl ID		ENSG00000135821	ENSG00000275074
Uniprot IDs		A8YXX4 P15104	Q6ZVK8
PDB IDs		2OJW 2QC8	3GG6 4HVY
Enriched GO Terms of Interacting Partners?
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