GHR and DUSP7

Data Source:
BioGRID (pull down)

		GHR	DUSP7
Description		growth hormone receptor	dual specificity phosphatase 7
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Cytoplasmic Ribonucleoprotein Granule Receptor Complex Growth Hormone Receptor Complex	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Cytokine Receptor Activity Growth Hormone Receptor Activity Protein Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Cytokine Binding Identical Protein Binding Protein Homodimerization Activity Proline-rich Region Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Activation Of MAPK Activity Endocytosis Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Taurine Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Activation Of Janus Kinase Activity Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT	MAPK Cascade Activation Of MAPK Activity Inactivation Of MAPK Activity Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation Negative Regulation Of MAP Kinase Activity
Pathways		Prolactin receptor signaling Growth hormone receptor signaling Growth hormone receptor signaling	RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs		Somatotropin Pegvisomant Somatrem Somapacitan
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Blood protein levels ( 30072576 29875488) Familial squamous cell lung carcinoma ( 29924316) Heel bone mineral density ( 30598549) Height ( 28552196 25429064 31562340) Iron status biomarkers ( 19084217) Menarche (age at onset) ( 25231870) Plasma renin activity levels ( 29650764) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)
Interacting Genes		44 interacting genes: AP2A1 BTRC CISH CUL1 CUL5 DUSP7 ELOB ELOC FBXO31 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 NEDD8 PIK3R1 PIK3R2 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH RBX1 RNF7 SGTA SHC1 SKP1 SOCS1 SOCS2 SOCS3 SRPK2 STAT3 STAT5A STAT5B STUB1 TYK2	7 interacting genes: EEF1A1 EGLN3 GHR IL16 MAPK1 MAPK14 MAPK8
Entrez ID		2690	1849
HPRD ID		02971	04125
Ensembl ID		ENSG00000112964	ENSG00000164086
Uniprot IDs		A0A087X0H5 A0A087X162 P10912	Q16829
PDB IDs		1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR 5OEK 5OHD	4Y2E
Enriched GO Terms of Interacting Partners?
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