HIC2 and CCNT1

Data Source:
HPRD (two hybrid, in vivo)

		HIC2	CCNT1
Description		HIC ZBTB transcriptional repressor 2	cyclin T1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Nucleolus Cytosol Cyclin/CDK Positive Transcription Elongation Factor Complex P-TEFb Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein C-terminus Binding Metal Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding Transcription Factor Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity RNA Polymerase Binding 7SK SnRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Cell Cycle Viral Process Positive Regulation Of DNA-templated Transcription, Elongation SnRNA Transcription By RNA Polymerase II Positive Regulation By Host Of Viral Transcription Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Cell Division Negative Regulation Of MRNA Polyadenylation
Pathways			Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Mean corpuscular volume ( 20139978) Systemic lupus erythematosus ( 19838193)	Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		9 interacting genes: APP CCNT1 CEP70 CRBN EHMT2 HIC1 MFHAS1 PDK2 ZBTB8A	26 interacting genes: AFF4 AHR BRD4 CDK9 CEBPB ESR1 GRIPAP1 GRN GTF2F1 HEXIM1 HEXIM2 HIC2 HTATSF1 HTN1 KAT2B MDFIC MYC NCOA2 NUFIP1 PML POLR2A PRKCI PURA RN7SK SKP2 SUPT5H
Entrez ID		23119	904
HPRD ID		07412	03938
Ensembl ID		ENSG00000169635	ENSG00000129315
Uniprot IDs		Q96JB3	A8K4M5 O60563
PDB IDs			2PK2 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH
Enriched GO Terms of Interacting Partners?
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