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ELN and ELANE
Data Source:
HPRD
(in vitro)
ELN
ELANE
Description
elastin
elastase, neutrophil expressed
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Matrix
Collagen-containing Extracellular Matrix
Elastic Fiber
Extracellular Region
Extracellular Space
Cytoplasm
Cell Surface
Transcription Repressor Complex
Secretory Granule
Azurophil Granule Lumen
Specific Granule Lumen
Phagocytic Vesicle
Collagen-containing Extracellular Matrix
Extracellular Exosome
Molecular Function
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Constituent Conferring Elasticity
Extracellular Matrix Binding
Protease Binding
Transcription Corepressor Activity
Endopeptidase Activity
Serine-type Endopeptidase Activity
Protein Binding
Heparin Binding
Peptidase Activity
Cytokine Binding
Biological Process
Outflow Tract Morphogenesis
Aortic Valve Morphogenesis
Skeletal Muscle Tissue Development
Respiratory Gaseous Exchange By Respiratory System
Blood Circulation
Animal Organ Morphogenesis
Extracellular Matrix Organization
Regulation Of Actin Filament Polymerization
Stress Fiber Assembly
Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Transcription By RNA Polymerase II
Response To Yeast
Acute Inflammatory Response To Antigenic Stimulus
Leukocyte Migration Involved In Inflammatory Response
Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria
Proteolysis
Cellular Calcium Ion Homeostasis
Phagocytosis
Response To UV
Antimicrobial Humoral Response
Extracellular Matrix Disassembly
Protein Catabolic Process
Response To Lipopolysaccharide
Negative Regulation Of Chemokine Production
Negative Regulation Of Interleukin-8 Production
Positive Regulation Of Interleukin-8 Production
Defense Response To Bacterium
Neutrophil Degranulation
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Inflammatory Response
Positive Regulation Of Immune Response
Negative Regulation Of Chemotaxis
Neutrophil-mediated Killing Of Gram-negative Bacterium
Neutrophil-mediated Killing Of Fungus
Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways
Degradation of the extracellular matrix
Elastic fibre formation
Molecules associated with elastic fibres
Molecules associated with elastic fibres
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Neutrophil degranulation
Antimicrobial peptides
Regulation of Complement cascade
Drugs
Rofecoxib
Alpha-1-proteinase inhibitor
Filgrastim
Mdl 101,146
Freselestat
Elafin
Diseases
Congenital supravalvar aortic stenosis
Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS
Diverticular disease (
30177863
)
Height (
31562340
)
Blood protein levels (
30072576
)
Interacting Genes
22 interacting genes:
ASS1
BGN
CKMT2
CLU
DCN
ELANE
FBLN1
FBLN2
FBN1
FBN2
FCN1
FKBP10
LGALS3
LOX
LOXL1
LYZ
MAGEH1
MFAP2
MTDH
NID2
PRTN3
SPINK1
30 interacting genes:
CAMP
CSF3
CSF3R
CXCL12
CXCR4
ELN
F2R
F2RL1
F5
GRN
ITGAM
KNG1
LPA
LRP1
NOTCH2NLA
SDC1
SERPINA1
SERPINA3
SERPINB1
SERPINB13
SERPIND1
SERPINE1
SERPINF2
SERPING1
SLPI
TFPI
TGFA
THBS1
VCAM1
YARS1
Entrez ID
2006
1991
HPRD ID
00556
00554
Ensembl ID
ENSG00000049540
ENSG00000197561
Uniprot IDs
B3KRT8
B4E3S4
E7EN65
E7ENM0
G3V0G6
G5E950
P15502
Q59H17
Q6ZUN2
Q8NBI4
P08246
PDB IDs
1B0F
1H1B
1HNE
1PPF
1PPG
2RG3
2Z7F
3Q76
3Q77
4NZL
4WVP
5A09
5A0A
5A0B
5A0C
5A8X
5A8Y
5A8Z
5ABW
6E69
6F5M
6SMA
7CBK
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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