AMOT and PTPN14

Data Source:
BioGRID (two hybrid)

		AMOT	PTPN14
Description		angiomotin	protein tyrosine phosphatase non-receptor type 14
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GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytosol Actin Filament Plasma Membrane Bicellular Tight Junction COP9 Signalosome External Side Of Plasma Membrane Lamellipodium Cell Junction Endocytic Vesicle Cytoplasmic Vesicle	Nucleus Nucleoplasm Cytoplasm Cytoskeleton
	Molecular Function	Protein Binding Signaling Receptor Activity Angiostatin Binding	Transcription Coregulator Activity Protein Tyrosine Phosphatase Activity Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Angiogenesis Vasculogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Chemotaxis Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Migration Negative Regulation Of GTPase Activity Cellular Protein Localization Hippo Signaling Positive Regulation Of Embryonic Development Cell Migration Involved In Gastrulation Blood Vessel Endothelial Cell Migration Regulation Of Small GTPase Mediated Signal Transduction	Lymphangiogenesis Regulation Of Transcription, DNA-templated Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Peptidyl-tyrosine Dephosphorylation Regulation Of Protein Export From Nucleus Cellular Response To Cytokine Stimulus
Pathways			Interleukin-37 signaling
Drugs
Diseases			Choanal atresia and lymphedema
GWAS			Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Birth weight ( 31043758) Bone mineral density (hip) ( 30172743) Estimated glomerular filtration rate ( 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Height ( 28552196 25429064 31562340) Lipid traits ( 24386095) Plasma thyroid-stimulating hormone levels ( 24722205)
Interacting Genes		60 interacting genes: ACTA1 AMOTL2 AP1M1 APP AQP1 AXIN2 C1orf216 CAPN3 DISC1 FHL2 HOXA1 HPCAL1 KIAA1328 KRT14 KRT15 KRT16 KRT19 KRT24 KRT27 KRT31 KRT34 KRT36 KRT75 LCE1D LMNB2 LMO4 LURAP1 LZTS1 MAGEA4 MAGI1 MAPK3 MED4 MEOX2 MIS18A MYBPC1 MYBPC2 MYOM3 NEDD4 NEDD4L NF2 NTAQ1 NUFIP2 PBLD PIBF1 PIK3C2A PIN1 PLG PRKAA2 PTEN PTPA PTPN14 RBM48 SEPTIN1 SLIRP SMC1A SNAPC5 SOCS6 THRA TTN UNC119	8 interacting genes: AMOT CDH1 CTNNA2 CTNNB1 JUP TJP1 TRIP6 YWHAG
Entrez ID		154796	5784
HPRD ID		02327	04402
Ensembl ID		ENSG00000126016	ENSG00000152104
Uniprot IDs		Q4VCS5	A8K6H6 Q15678
PDB IDs		6JJX	2BZL 6IWD 6JJW
Enriched GO Terms of Interacting Partners?
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