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EGLN3 and WDR83
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
EGLN3
WDR83
Description
egl-9 family hypoxia inducible factor 3
WD repeat domain 83
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Spliceosomal Complex
Endosome Membrane
Catalytic Step 2 Spliceosome
Molecular Function
Protein Binding
Ferrous Iron Binding
2-oxoglutarate-dependent Dioxygenase Activity
L-ascorbic Acid Binding
Peptidyl-proline Dioxygenase Activity
Peptidyl-proline 4-dioxygenase Activity
Protein Binding
Biological Process
Response To Hypoxia
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Response To DNA Damage Stimulus
Protein Hydroxylation
Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
Regulation Of Cell Population Proliferation
Regulation Of Neuron Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hypoxia
MAPK Cascade
RNA Splicing, Via Transesterification Reactions
MRNA Splicing, Via Spliceosome
Response To Hypoxia
Response To Lipopolysaccharide
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Inflammatory Response To Wounding
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
MAP2K and MAPK activation
Drugs
Ascorbic acid
Roxadustat
Diseases
GWAS
Alzheimer's disease (late onset) (
30820047
)
Daytime sleep phenotypes (
27126917
)
Hematocrit (
32888494
27863252
)
Hemoglobin (
32888494
)
Red blood cell count (
32888494
)
Interacting Genes
38 interacting genes:
ABI2
ADRB2
ATF4
CTBP2
DUSP7
EFHC2
EPAS1
EPOR
FAM168B
FOXJ2
GSC2
HIF1A
HIF3A
IK
IKBKG
IKZF3
LDB2
LNX1
MAPK1
MAPK7
MDM2
NCAPH2
NTAQ1
OS9
PKM
PLEKHA2
PRPF19
RBBP8NL
SERTAD1
SIAH2
SUMO1
SUMO2
SUMO3
TP53
TTC23L
WDR83
ZC2HC1A
ZNF655
30 interacting genes:
BAG2
BCL6
CRB3
CRK
EGLN3
FAM124B
FRS3
GNE
GPKOW
HNRNPH2
HOXA1
HSPB1
KCTD9
KDM1A
KEAP1
LONRF1
LSM3
NOXA1
PARD6A
PARD6B
PCBP2
PRKAB2
RACK1
SAP30BP
SF1
TLX3
TOE1
VAC14
WBP4
ZNF76
Entrez ID
112399
84292
HPRD ID
06972
14730
Ensembl ID
ENSG00000129521
ENSG00000123154
Uniprot IDs
B3KVT0
F8W1G2
Q3T1B0
Q9H6Z9
Q9BRX9
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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