CENPB and PARP2

Data Source:
HPRD (in vivo)

		CENPB	PARP2
Description		centromere protein B	poly(ADP-ribose) polymerase 2
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Nuclear Body	Nucleoplasm Nucleolus
	Molecular Function	DNA Binding Chromatin Binding Satellite DNA Binding Centromeric DNA Binding Sequence-specific DNA Binding	DNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding NAD DNA ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity
	Biological Process		DNA Repair Base-excision Repair Double-strand Break Repair Protein ADP-ribosylation Peptidyl-serine ADP-ribosylation DNA ADP-ribosylation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Protein Poly-ADP-ribosylation Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Death
Pathways			POLB-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER
Drugs			Veliparib Olaparib Talazoparib Niraparib Rucaparib
Diseases
GWAS			Menopause (age at onset) ( 26414677)
Interacting Genes		20 interacting genes: ADRB2 ANXA7 APP CDKN1A CENPW CSNK2B FBXO25 GADD45A GFI1B GSK3B HAND2 NR3C1 PARP1 PARP2 PIN1 RPS6KA6 SH2D3A SMN1 TAC1 TK1	13 interacting genes: BUB3 CASP8 CENPA CENPB H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HPF1 PARP1 XRCC1
Entrez ID		1059	10038
HPRD ID		00314	09660
Ensembl ID		ENSG00000125817	ENSG00000129484
Uniprot IDs		P07199	Q9UGN5
PDB IDs		1BW6 1HLV 1UFI 6KDR	3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY 6F1K 6F5B 6F5F 6TX3 6USJ 6X0L 6X0M 6X0N
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?