SIVA1 and MEFV

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SIVA1	MEFV
Description		SIVA1 apoptosis inducing factor	MEFV innate immuity regulator, pyrin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Ruffle Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Microtubule Microtubule Associated Complex Lamellipodium Cytoplasmic Vesicle
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Binding CD27 Receptor Binding Protein Binding Metal Ion Binding	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Viral Entry Into Host Cell Extrinsic Apoptotic Signaling Pathway	Inflammatory Response Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Response To Interferon-gamma Innate Immune Response Negative Regulation Of Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways			The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS		Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401) Thyroid stimulating hormone levels ( 32769997)	Ankylosing spondylitis ( 30946743)
Interacting Genes		30 interacting genes: ABL2 APP AQP1 BCL2L1 BEX3 C2orf68 CATSPER1 CD27 CD4 CDKN2A CREB5 HOXA1 ING3 KRTAP26-1 MEFV NEDD4 NEDD4L NTAQ1 PCNA PM20D2 POLR2M PXMP2 RAD18 RHOU SSBP3 TCAP TFAP2D TNFRSF4 UBE2D1 ZNF446	12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1
Entrez ID		10572	4210
HPRD ID		16124	02012
Ensembl ID		ENSG00000184990	ENSG00000103313
Uniprot IDs		O15304	D2DTW2 O15553
PDB IDs			2MPC 2WL1 4CG4
Enriched GO Terms of Interacting Partners?
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