TADA3 and TXNRD2

Data Source:
BioGRID (two hybrid)

		TADA3	TXNRD2
Description		transcriptional adaptor 3	thioredoxin reductase 2
Image		No pdb structure
GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex STAGA Complex Transcription Factor TFTC Complex Mitotic Spindle	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Nuclear Receptor Binding Protein Domain Specific Binding Nuclear Receptor Coactivator Activity	Thioredoxin-disulfide Reductase Activity Protein Binding Flavin Adenine Dinucleotide Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Protein Phosphorylation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Protein Deubiquitination Intracellular Estrogen Receptor Signaling Pathway Regulation Of Histone Deacetylation Regulation Of Protein Stability Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Regulation Of Tubulin Deacetylation	Response To Oxygen Radical Cellular Response To Oxidative Stress Cell Redox Homeostasis Cellular Oxidant Detoxification
Pathways		HATs acetylate histones Ub-specific processing proteases	Detoxification of Reactive Oxygen Species
Drugs			Motexafin gadolinium
Diseases
GWAS			Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary angle closure) ( 22922875) Glaucoma (primary open-angle) ( 26752265 29891935) Intraocular pressure ( 29785010 31959993 30054594) Lean body mass ( 28552196) Staphylococcus aureus infection ( 24847357)
Interacting Genes		32 interacting genes: ADPGK ANKRD12 ANKRD36B AR CCNC EIF3J EP300 ESR1 FAM107B H3-4 HEXIM2 HSPA8 ING5 KDM1A MAGEH1 MFHAS1 NR1I2 PIAS4 RARA RFX1 RXRA RXRB SAP18 SGF29 STX11 TADA2A TP53 TXLNB TXNRD2 USP5 XRCC6 ZNF7	7 interacting genes: BCAS2 GTF2H1 NCOA2 NCOA6 NCOR1 PSMC3 TADA3
Entrez ID		10474	10587
HPRD ID		04252	18519
Ensembl ID		ENSG00000171148	ENSG00000184470
Uniprot IDs		A0A024R2D7 A8K899 O75528	E7EWK1 Q9NNW7
PDB IDs			1W1E
Enriched GO Terms of Interacting Partners?
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