OPTN and RAB12

Data Source:
BioGRID (two hybrid)

		OPTN	RAB12
Description		optineurin	RAB12, member RAS oncogene family
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Autophagosome Golgi Apparatus Trans-Golgi Network Cytosol Perinuclear Region Of Cytoplasm Recycling Endosome Membrane	Golgi Membrane Lysosome Lysosomal Membrane Endosome Autophagosome Golgi Apparatus Cytosol Plasma Membrane Synaptic Vesicle Insulin-responsive Compartment Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Receptor Recycling Autophagy Golgi Organization Signal Transduction Cell Death Positive Regulation Of Autophagy Viral Process Protein Localization To Golgi Apparatus Cellular Response To Unfolded Protein Golgi To Plasma Membrane Protein Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Defense Response To Gram-negative Bacterium Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization Golgi Ribbon Formation Positive Regulation Of Xenophagy	Vesicle Docking Involved In Exocytosis Autophagy Endosome To Lysosome Transport Protein Secretion Regulation Of Exocytosis Rab Protein Signal Transduction Cellular Response To Insulin Stimulus Cellular Protein Catabolic Process Protein Localization To Plasma Membrane
Pathways		Regulation of PLK1 Activity at G2/M Transition TBC/RABGAPs	RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Primary open angle glaucoma
GWAS		Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Paget's disease ( 21623375 20436471)	Metabolite levels ( 23823483) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		69 interacting genes: AIMP1 ARRDC3 ATG16L1 ATG5 CALM1 CCDC13 CDC23 CLTC CMYA5 DAZAP2 DYSF DZIP1 FAM189A2 FLII FOS FTH1 GABARAP GABARAPL1 GABARAPL2 GNAS GRM1 GTF3A HACE1 HSF2BP HSPB1 HTT IRAK1 KANSL1L LITAF LNX2 MAP1LC3A MAP1LC3C MPP1 MYH3 MYO6 PIAS4 PICK1 POU6F2 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RBM12 RFFL RNF11 RNF216 SDCBP SLF2 SNX6 TBC1D15 TBC1D17 TNIP1 UBB UBC UQCRQ USP2 VCP WASHC3 WIPI2 ZNF17 ZNF181 ZNF302 ZNF329 ZNF398 ZNF426 ZNF670 ZNF711	1 interacting genes: OPTN
Entrez ID		10133	201475
HPRD ID		03891	18749
Ensembl ID		ENSG00000123240	ENSG00000206418
Uniprot IDs		Q96CV9	Q6IQ22
PDB IDs		2LO4 2LUE 3VTV 3VTW 5AAZ 5B83 5EOA 5EOF	2IL1
Enriched GO Terms of Interacting Partners?
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