SYCE1 and ALOX5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		SYCE1	ALOX5
Description		synaptonemal complex central element protein 1	arachidonate 5-lipoxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Central Element Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Nuclear Envelope Nuclear Envelope Lumen Nucleoplasm Cytosol Plasma Membrane Nuclear Matrix Nuclear Membrane Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding	Arachidonate 5-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen
	Biological Process	Synaptonemal Complex Assembly Cell Division	Leukocyte Chemotaxis Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Leukotriene Metabolic Process Cytokine-mediated Signaling Pathway Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Lipid Oxidation Interleukin-18-mediated Signaling Pathway Long-chain Fatty Acid Biosynthetic Process Neutrophil Degranulation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Hepoxilin Biosynthetic Process Oxidation-reduction Process Lipoxin Biosynthetic Process
Pathways		Meiotic synapsis	Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX) Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Interleukin-18 signaling Biosynthesis of D-series resolvins Biosynthesis of maresins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-3-derived protectins and resolvins Biosynthesis of DPAn-3-derived maresins Biosynthesis of DPAn-3-derived 13-series resolvins Biosynthesis of electrophilic Ï‰-3 PUFA oxo-derivatives
Drugs			Vitamin E Masoprocol Aminosalicylic Acid Mesalazine Montelukast Diclofenac Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Resveratrol Licofelone MLN-977 Diacerein Rhein
Diseases
GWAS			Cholesterol, total ( 24097068) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Total cholesterol levels ( 28334899)
Interacting Genes		36 interacting genes: ALOX5 ARNT2 BFSP2 CBY2 CCDC102B CINP CNN1 CYTH3 EDRF1 FAM161A HAUS1 HMG20B HOOK1 HSPB1 HSPB7 IQUB KIFC3 KRT18 LMNA MPV17 MRFAP1L1 NME7 PSTPIP1 RBCK1 SCNM1 SKA1 SMARCE1 SSX2 STX19 TFIP11 TPM1 TPM3 TRAF1 TSG101 WASHC3 ZNF124	19 interacting genes: ACTB ALOX5AP ALPL APP CEP57L1 CEP63 COTL1 DICER1 GRB2 HHIPL2 LTC4S MAD1L1 MAPKAPK2 MEOX1 MTDH NUTM1 REL SYCE1 TGFBRAP1
Entrez ID		93426	240
HPRD ID		12598	01065
Ensembl ID		ENSG00000171772	ENSG00000012779
Uniprot IDs		A0A0B4J1R9 Q8N0S2	P09917
PDB IDs			2ABV 3O8Y 3V92 3V98 3V99
Enriched GO Terms of Interacting Partners?
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