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CD247 and PTPN6
Number of citations of the paper that reports this interaction (PubMedID
14672952
)
22
Data Source:
HPRD
(in vivo, in vitro)
CD247
PTPN6
Description
CD247 molecule
protein tyrosine phosphatase non-receptor type 6
Image
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Membrane
T Cell Receptor Complex
Alpha-beta T Cell Receptor Complex
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cell-cell Junction
Membrane
Protein-containing Complex
Specific Granule Lumen
Alpha-beta T Cell Receptor Complex
Extracellular Exosome
Tertiary Granule Lumen
Molecular Function
Transmembrane Signaling Receptor Activity
Protein Binding
Identical Protein Binding
Protein Tyrosine Kinase Binding
Phosphotyrosine Residue Binding
Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
SH2 Domain Binding
Cell Adhesion Molecule Binding
Phosphorylation-dependent Protein Binding
Biological Process
Adaptive Immune Response
Interleukin-2 Production
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Defense Response To Virus By Virus
Regulation Of Immune Response
T Cell Receptor Signaling Pathway
Positive Regulation Of Protein Localization To Cell Surface
Hematopoietic Progenitor Cell Differentiation
Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Protein Dephosphorylation
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Platelet Activation
Platelet Formation
T Cell Costimulation
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Abortive Mitotic Cell Cycle
Positive Regulation Of Cell Adhesion Mediated By Integrin
Peptidyl-tyrosine Dephosphorylation
Intracellular Signal Transduction
Megakaryocyte Development
Negative Regulation Of T Cell Proliferation
Natural Killer Cell Mediated Cytotoxicity
Regulation Of Apoptotic Process
Neutrophil Degranulation
Negative Regulation Of MAP Kinase Activity
Regulation Of B Cell Differentiation
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
B Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Leukocyte Migration
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Cellular Response To Cytokine Stimulus
Epididymis Development
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
GPVI-mediated activation cascade
Regulation of KIT signaling
PECAM1 interactions
Costimulation by the CD28 family
PD-1 signaling
Signal regulatory protein family interactions
Platelet sensitization by LDL
Interleukin-3, Interleukin-5 and GM-CSF signaling
CD22 mediated BCR regulation
Neutrophil degranulation
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-37 signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA signaling
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Muromonab
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
29785011
)
Allergic rhinitis (
31361310
)
Asthma (
31361310
30929738
27182965
31619474
)
Asthma (adult onset) (
30929738
)
Asthma (childhood onset) (
30929738
)
Asthma (moderate or severe) (
30552067
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Celiac disease (
20190752
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Medication use (adrenergics, inhalants) (
31015401
)
Medication use (glucocorticoids) (
31015401
)
Medication use (thyroid preparations) (
31015401
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Rheumatoid arthritis (
20453842
)
Systemic sclerosis (
21750679
31672989
20383147
29293537
21779181
)
Mean corpuscular hemoglobin concentration (
29403010
)
Red blood cell fatty acid levels (
25500335
)
Interacting Genes
38 interacting genes:
CD2
CD244
CD28
CD3D
CD48
CD5
CSK
DOCK2
FCGR3A
FYN
GAB2
GRB2
JAK3
LCK
LY6E
NCR1
NCR3
PCGF2
PI4K2B
PTPN22
PTPN3
PTPN6
PTPRC
SH2B3
SHC1
SLA
SLA2
STAT5A
STAT5B
TFRC
TIRAP
TRA
TRAT1
TRB
UNC119
VTN
ZAP70
ZNF281
114 interacting genes:
AATK
ABL1
ACTN1
ACTN4
BCR
BLNK
BTLA
CAV1
CBL
CCDC88A
CD22
CD247
CD300LF
CD33
CD5
CD72
CD79A
CD79B
CDK1
CEACAM1
CLEC4A
CSF2RB
CTNNB1
CTNND1
CUZD1
CXCR4
DOK1
EGFR
EPOR
ERBB2
ERBB3
ERBB4
ESR1
FAS
FCGR2B
FCRL3
FGFR4
FHL3
FLT3
GAB2
GHR
GRB2
HOXA10
IFNAR1
IGF1R
IL2RB
IL4R
IL6ST
INSR
IRS2
IRS4
JAK1
JAK2
JAK3
KDR
KHDRBS1
KIR2DL3
KIR2DL5A
KIT
KLRA1P
KLRB1
KLRC1
LAIR1
LAT
LCK
LCP2
LIFR
LILRB2
LILRB4
LMTK2
LYN
MPIG6B
MS4A2
MYH9
NOS1
OLIG1
PAG1
PDGFRB
PECAM1
PIK3R1
PILRA
PILRB
PLCG2
PRKCA
PRKCD
PTK2B
PTK7
PTPN11
PTPRC
ROR1
ROR2
ROS1
SHC1
SIGLEC10
SIGLEC11
SIGLEC12
SIRPA
SLAMF6
SOS1
SPATA2
SRC
SSTR2
STAT5B
STAT6
SYK
TFG
TLR10
TMEM62
TNFRSF1A
TRAF6
TREML1
TYK2
VAV1
ZAP70
Entrez ID
919
5777
HPRD ID
01729
01475
Ensembl ID
ENSG00000198821
ENSG00000111679
Uniprot IDs
P20963
P29350
Q53XS4
PDB IDs
1TCE
1YGR
2HAC
2OQ1
3IK5
3IOZ
4XZ1
6JXR
1FPR
1GWZ
1X6C
2B3O
2RMX
2YU7
3PS5
4GRY
4GRZ
4GS0
4HJP
4HJQ
Enriched GO Terms of Interacting Partners
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