PSTPIP1 and MEFV

Number of citations of the paper that reports this interaction (PubMedID 14595024)
94

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		PSTPIP1	MEFV
Description		proline-serine-threonine phosphatase interacting protein 1	MEFV innate immuity regulator, pyrin
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GO Annotations	Cellular Component	Uropod Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm	Ruffle Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Microtubule Microtubule Associated Complex Lamellipodium Cytoplasmic Vesicle
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Identical Protein Binding	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Innate Immune Response	Inflammatory Response Positive Regulation Of Autophagy Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Response To Interferon-gamma Negative Regulation Of Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases		Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome	Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS		Neurofibrillary tangles ( 31497858)	Ankylosing spondylitis ( 30946743)
Interacting Genes		42 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 DNM2 EXOC5 FAM90A1 FASLG FBXL18 HMG20A KHDRBS1 LSM4 MEFV MFGE8 MVP NAV2 PCDHB14 PRPF31 PTPN12 PTPN18 RINT1 RTP5 RXRB SDCBP SH2D4A SHBG SPG7 SYCE1 TFIP11 TRAF3IP3 TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZNF175 ZNF688	12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1
Entrez ID		9051	4210
HPRD ID		05891	02012
Ensembl ID		ENSG00000140368	ENSG00000103313
Uniprot IDs		A0A0S2Z5P3 O43586	D2DTW2 O15553
PDB IDs		2DIL	2MPC 2WL1 4CG4
Enriched GO Terms of Interacting Partners?
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