BECN1 and KAT2A

Number of citations of the paper that reports this interaction (PubMedID 28205554)
32

Data Source:
BioGRID (fluorescent resonance energy transfer)

		BECN1	KAT2A
Description		beclin 1	lysine acetyltransferase 2A
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Cell Nucleus Mitochondrion Endosome Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endosome Membrane Extrinsic Component Of Membrane Mitochondrial Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III	Histone Acetyltransferase Complex Nuclear Chromatin Extracellular Space Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Centrosome STAGA Complex Transcription Factor TFTC Complex Oxoglutarate Dehydrogenase Complex Mitotic Spindle
	Molecular Function	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Phosphatidylinositol 3-kinase Binding GTPase Binding	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding H3 Histone Acetyltransferase Activity Protein Phosphatase Binding Histone Deacetylase Binding Histone Acetyltransferase Activity (H4-K12 Specific) Peptide-lysine-N-acetyltransferase Activity Histone Succinyltransferase Activity
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Endocytosis Autophagy Apoptotic Process Cellular Defense Response Cellular Response To Nitrogen Starvation Mitotic Metaphase Plate Congression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Macroautophagy Protein Deubiquitination Protein Localization By The Cvt Pathway Regulation Of Cytokinesis Receptor Catabolic Process Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Early Endosome To Late Endosome Transport Late Endosome To Vacuole Transport Cell Division Defense Response To Virus Negative Regulation Of Cell Death Response To Mitochondrial Depolarisation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	In Utero Embryonic Development Somitogenesis Cytokine Production Neural Tube Closure Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Heart Development Long-term Memory Cell Proliferation Response To Organic Cyclic Compound Viral Process Histone Acetylation Histone Deubiquitination Protein Deubiquitination Internal Peptidyl-lysine Acetylation Telencephalon Development Metencephalon Development Midbrain Development Positive Regulation Of Cell Projection Organization Regulation Of Protein Stability Response To Nutrient Levels Positive Regulation Of Histone Acetylation Multicellular Organism Growth Histone H3 Acetylation Histone H4-K12 Acetylation Histone H3-K14 Acetylation Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Regulation Of T Cell Activation Limb Development Regulation Of Cartilage Development Cellular Response To Tumor Necrosis Factor Alpha-tubulin Acetylation Histone Succinylation Regulation Of Bone Development Cellular Response To Nerve Growth Factor Stimulus Regulation Of Stem Cell Population Maintenance Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Macroautophagy Ub-specific processing proteases	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HATs acetylate histones Notch-HLH transcription pathway B-WICH complex positively regulates rRNA expression Ub-specific processing proteases RNA Polymerase I Transcription Initiation RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs		Estradiol	Coenzyme A
Diseases
GWAS		Type 2 diabetes (age of onset) ( 28060188)	Coronary artery disease ( 29212778) Inflammatory bowel disease ( 26278503) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737)
Interacting Genes		50 interacting genes: AKT1 AMBRA1 ARAF ARNT ATG3 BCL2 BCL2L1 BTK CASP3 CCND2 CDK4 CDK6 CDKN2A CDKN2B EPHA2 ERBB2 FGFR4 FRS2 FZR1 GFI1B GLIS2 GOPC GRM1 ITCH KAT2A KDELR2 LATS2 MAP2K3 MAP2K5 MAP2K6 MAPKAPK2 MAPKAPK3 MDM4 NF2 PDGFRA PGK1 RACK1 RAF1 SHD SMAD2 STK11 TEAD2 TERT TRAF2 TSC1 UBC ULK1 WASHC1 XPO1 YES1	60 interacting genes: AKT1 ATXN7 BATF2 BECN1 CCND2 CCNE1 CDK2 CDK6 CDKN2B CEBPB COMMD1 CREBBP CRX CTNNB1 CUL2 DTL EID1 EP300 FZR1 GATA2 GRM1 H1-5 H2AC20 H2BC21 H3-4 H3C14 H4-16 H4C14 HSD11B2 IRF1 IRF2 IRF7 KDELR2 LATS2 MAP2K3 MAPK14 MYB MYC NF2 NOTCH1 PBX1 PPARG PRKDC PYGO2 RASSF1 RBPJ RELA SIRT2 STK11 TACC1 TACC2 TACC3 TADA2A TCF3 TP53 TRRAP TSC1 TTYH2 UBE2I XRCC6
Entrez ID		8678	2648
HPRD ID		05087	03807
Ensembl ID		ENSG00000126581	ENSG00000108773
Uniprot IDs		A0A024R1X5 B4DQ36 E7EV84 Q14457 W0FFG4	Q92830
PDB IDs		2P1L 2PON 3DVU 4DDP 4MI8 5EFM 5HHE 5VAU 5VAX 5VAY 6DCN 6DCO 6HOI 6HOJ 6HOK	1F68 1Z4R 3D7C 5H84 5H86 5MLJ 5TRL 5TRM 6J3P
Enriched GO Terms of Interacting Partners?
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