AXIN1 and MDFI

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		AXIN1	MDFI
Description		axin 1	MyoD family inhibitor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Lateral Plasma Membrane Beta-catenin Destruction Complex Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Cell Periphery	Nucleus Cytoplasm
	Molecular Function	Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity SMAD Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding I-SMAD Binding	Protein Binding Transcription Factor Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Apoptotic Process Multicellular Organism Development Positive Regulation Of Peptidyl-threonine Phosphorylation Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Ubiquitination Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Protein-containing Complex Assembly Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Destruction Complex Assembly Beta-catenin Destruction Complex Disassembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Dorsal/ventral Axis Specification Negative Regulation Of Wnt Signaling Pathway Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA Binding Embryonic Skeletal System Morphogenesis Trophoblast Giant Cell Differentiation
Pathways		Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Degradation of AXIN Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ub-specific processing proteases RUNX1 regulates estrogen receptor mediated transcription RUNX1 regulates transcription of genes involved in WNT signaling Estrogen-dependent gene expression
Drugs		1,4-Dithiothreitol
Diseases		Hepatocellular carcinoma Caudal duplication anomaly
GWAS		Body mass index ( 25673413) Bone mineral density (spine) ( 26733130) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 27863252) Red cell distribution width ( 27863252)	Grapefruit juice consumption ( 31046077) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)
Interacting Genes		83 interacting genes: AMER1 ANP32A APC BTRC CALCOCO2 CARD9 CARM1 CCDC57 CDCA7L CRMP1 CSNK1A1 CSNK1E CTNNB1 DAB2 DIXDC1 DVL1 DVL2 DVL3 EEF1A1 ENTR1 ETV6 GAK GMCL1 GNAS GOLGA2 GSK3B HOMEZ JUP KRT40 KRTAP10-3 KRTAP4-12 KRTAP4-2 LHX4 LHX8 LMO2 LRP5 LRP6 MAP3K4 MDFI MEOX2 MID2 MTUS2 MYC MYOT NBR1 NCK2 NUTM1 PIAS1 PML PPP2CA PPP2CB PPP2R5B PPP2R5C PRMT1 PSTPIP1 RNF111 RUNX2 SCYL1 SENP2 SH3GL1 SIAH1 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 STX11 SUMO1 SUMO1P1 TFIP11 TNKS TP53 TP53BP2 TRAF2 TRIM15 TRIM27 TRIM37 TRIM42 TRIP6 TSGA10 UTP14A ZBTB26 ZFYVE19	243 interacting genes: AANAT AASDHPPT ABCF3 ABHD17A ADAMTSL3 AKAP17A AP5Z1 APLN AQP1 AQP5 ARHGAP32 ARID5A ATG12 ATN1 ATP6V0C ATXN7L2 AVPI1 AXIN1 B3GNT9 BAALC BAHD1 BANP BBS2 BCL6 BEX1 C10orf62 C22orf39 C8orf33 C8orf48 CATSPER1 CBFA2T2 CBX2 CC2D1B CCDC116 CCDC120 CCDC185 CCDC198 CCDC33 CCER1 CDC42EP1 CDCA7L CDKL3 CEP57L1 CFAP206 CHIC2 CHRNG CLPB CNNM3 CREB5 CRX CRY1 CSNK1G2-AS1 CXCL16 CYBA DAAM2 DBF4B DCAF8 DCANP1 DDX19A DHRS1 DKK1 DMRT3 DNPEP DOCK2 DUSP6 EBI3 EIF4A2 EIF4E2 ELOA ENKD1 ETNK2 EWSR1 FAAP100 FAM124B FAM161A FAM27E3 FASTK FBXL18 FBXO34 FBXW5 FES FNDC11 FOXD4L6 FZD9 GATA1 GATA2 GDF15 GLIDR GLRX3 GNAI2 GNG5 GPATCH2L GPRIN2 GTF3C5 HEYL HNRNPLL HOXA1 HOXB9 HTR1B ILF3 INTS11 IQUB KANSL1 KAT5 KIAA0040 KIAA0408 KIF1A KPNA2 KRAS LAMB3 LASP1 LCE1B LCE3E LCE4A LIMS2 LINC00636 LINC01588 LMO3 LRCH4 LRRN4 MACIR MAGED1 MAGEF1 MAPKBP1 MCM5 MEOX2 METTL17 MFSD3 MGAT5B MRPL20-AS1 MVP MYF5 MYOD1 MYOG NAB2 NDUFA7 NECTIN2 NEU4 NOL4L-DT NPDC1 NR1H2 NR1H3 NTAQ1 ODAPH OLIG3 OTX1 PARP11 PBXIP1 PDGFB PDIA5 PGLS PHLDA1 PID1 PIDD1 PIH1D2 PIN1 PLEKHG4 POM121L8P PRKAB2 PRPF31 PTPMT1 RABL6 REG3A REX1BD RFX2 RIPPLY1 RNF6 RTP5 SERF2 SFI1 SHFL SIX1 SLC25A10 SLC35A2 SLC9A1 SPATA3 SPATA8 SPG7 SPRY1 SPRY2 TAP1 TCF3 TEAD4 TGIF1 THAP7 THEG TIE1 TINAGL1 TMEM241 TNNI1 TNP2 TRAF3IP2 TRIB3 TRPC1 TRPV6 TSC2 TTC23 TTC25 TTLL10 TUSC2 TYMSOS TYRO3 USP20 USP6 VHL VPS72 WDFY3 WNT11 ZBTB24 ZBTB25 ZBTB9 ZFYVE26 ZNF101 ZNF124 ZNF136 ZNF138 ZNF155 ZNF205 ZNF223 ZNF230 ZNF264 ZNF266 ZNF408 ZNF417 ZNF426 ZNF433 ZNF439 ZNF440 ZNF490 ZNF559 ZNF564 ZNF578 ZNF581 ZNF587 ZNF607 ZNF646 ZNF670 ZNF679 ZNF688 ZNF707 ZNF764 ZNF79 ZNF844
Entrez ID		8312	4188
HPRD ID		04819	07280
Ensembl ID		ENSG00000103126	ENSG00000112559
Uniprot IDs		A0A0S2Z4R0 A0A0S2Z4S3 O15169	A0A024RCY2 B1AKB6 Q99750
PDB IDs		1DK8 1EMU 1O9U 3ZDI 4B7T 4NM0 4NM3 4NM5 4NM7 4NU1 5WZZ
Enriched GO Terms of Interacting Partners?
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