CALR and SLC2A1

Number of citations of the paper that reports this interaction (PubMedID 8662691)
8

Data Source:
HPRD (in vivo)

		CALR	SLC2A1
Description		calreticulin	solute carrier family 2 member 1
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GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Cell Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Polysome Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Phagocytic Vesicle Membrane Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Endocytic Vesicle Lumen	Golgi Membrane Female Pronucleus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Z Disc Midbody Cortical Actin Cytoskeleton Sarcolemma Melanosome Extracellular Exosome Blood Microparticle Presynapse
	Molecular Function	Complement Component C1q Binding DNA Binding RNA Binding MRNA Binding Integrin Binding Iron Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Carbohydrate Binding Ubiquitin Protein Ligase Binding Peptide Binding Hormone Binding Protein Binding Involved In Protein Folding Androgen Receptor Binding Unfolded Protein Binding Chaperone Binding	Glucose Transmembrane Transporter Activity Protein Binding Kinase Binding Dehydroascorbic Acid Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity Protein Self-association D-glucose Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Transcription, DNA-templated Protein Folding Protein Export From Nucleus Cellular Calcium Ion Homeostasis Receptor-mediated Endocytosis Spermatogenesis Positive Regulation Of Cell Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Translation Protein Maturation By Protein Folding Cortical Actin Cytoskeleton Organization Endoplasmic Reticulum Unfolded Protein Response Response To Estradiol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Testosterone Protein Localization To Nucleus Protein Folding In Endoplasmic Reticulum ATF6-mediated Unfolded Protein Response Regulation Of Meiotic Nuclear Division Response To Drug Glucocorticoid Receptor Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phagocytosis Protein Stabilization Sequestering Of Calcium Ion Cardiac Muscle Cell Differentiation Negative Regulation Of Cell Cycle Arrest Cellular Response To Lithium Ion Cellular Senescence Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Trophoblast Cell Migration Positive Regulation Of NIK/NF-kappaB Signaling Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane Positive Regulation Of Dendritic Cell Chemotaxis	Response To Hypoxia Lactose Biosynthetic Process Female Pregnancy Regulation Of Glucose Transmembrane Transport L-ascorbic Acid Metabolic Process Cerebral Cortex Development Response To Insulin Cellular Response To Glucose Starvation Xenobiotic Transport Regulation Of Insulin Secretion Protein-containing Complex Assembly Dehydroascorbic Acid Transport Cellular Response To Mechanical Stimulus Cellular Hyperosmotic Response Response To Thyroglobulin Triiodothyronine Glucose Transmembrane Transport
Pathways		ER-Phagosome pathway Assembly of Viral Components at the Budding Site Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors ATF6 (ATF6-alpha) activates chaperone genes Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Cellular hexose transport Vitamin C (ascorbate) metabolism Regulation of insulin secretion Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) Lactose synthesis
Drugs		Antihemophilic factor, human recombinant Tenecteplase Melatonin Copper Calcium Citrate Calcium Phosphate	Resveratrol
Diseases			GLUT1 deficiency syndrome (GLUT1DS); Glucose transport defect of the blood-brain barrier Primary torsion dystonia (PTD)
GWAS		Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Red blood cell traits ( 23222517)	Birth weight ( 31043758) Cardiac hypertrophy ( 21348951) Monocyte count ( 27863252) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		46 interacting genes: APOB APP AR B2M CD1D F5 F8 FBN1 FGB HLA-A HLA-C HLA-E ITGA2B ITGA3 ITGAV LPL LRIF1 LRP1 MAPK6 MBL2 MTNR1A NKX2-1 NR3C1 PDIA2 PDIA3 PLAT PLP1 PRF1 PTPN11 RNY1 RNY3 RNY4 SCARF1 SIRPA SLC2A1 SLC6A4 SMARCB1 SUMO4 TAPBP TF THBS1 TRIM21 TSHR UBE3A UPF2 VWF	13 interacting genes: CALR CANX COPS6 GAPDH GIPC1 HSPB2 PDIA3 PTK2B SNX27 STOM SUMO1 UBE2I VHL
Entrez ID		811	6513
HPRD ID		00169	00683
Ensembl ID		ENSG00000179218	ENSG00000117394
Uniprot IDs		P27797 V9HW88	P11166 Q59GX2
PDB IDs		2CLR 3DOW 3POS 3POW 5LK5 5V90 6ENY	1SUK 4PYP 5EQG 5EQH 5EQI
Enriched GO Terms of Interacting Partners?
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