TP53 and AKT1

Number of citations of the paper that reports this interaction (PubMedID 28205554)
32

Data Source:
BioGRID (fluorescent resonance energy transfer)

		TP53	AKT1
Description		tumor protein p53	AKT serine/threonine kinase 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Replication Fork Transcription Factor Complex Transcription Factor TFIID Complex Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum Centrosome Cytosol Nuclear Matrix Nuclear Body PML Body Nuclear Membrane Protein-containing Complex Site Of Double-strand Break	Nucleus Nucleoplasm Cytoplasm Mitochondrion Spindle Cytosol Plasma Membrane Cell-cell Junction Microtubule Cytoskeleton Vesicle Protein-containing Complex Ciliary Basal Body Postsynapse
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding TFIID-class Transcription Factor Complex Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protease Binding P53 Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity MRNA 3'-UTR Binding Copper Ion Binding Protein Binding ATP Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Regulator Activity Histone Acetyltransferase Binding Identical Protein Binding Histone Deacetylase Binding Protein Self-association Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Protein N-terminus Binding Chaperone Binding Protein Phosphatase 2A Binding MDM2/MDM4 Family Protein Binding Disordered Domain Specific Binding Promoter-specific Chromatin Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase C Binding Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Kinase Activity Enzyme Binding Nitric-oxide Synthase Regulator Activity GTPase Activating Protein Binding Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Phosphatase 2A Binding 14-3-3 Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Strand Renaturation In Utero Embryonic Development Somitogenesis Release Of Cytochrome C From Mitochondria Hematopoietic Progenitor Cell Differentiation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment T Cell Lineage Commitment Response To Ischemia Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription, DNA-templated Protein Import Into Nucleus Autophagy Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator ER Overload Response Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Ras Protein Signal Transduction Gastrulation Negative Regulation Of Neuroblast Proliferation Cell Aging Protein Localization Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Determination Of Adult Lifespan MRNA Transcription RRNA Transcription Response To Salt Stress Response To X-ray Response To Gamma Radiation Positive Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Viral Process Protein Deubiquitination Cytokine-mediated Signaling Pathway Cerebellum Development Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Histone Deacetylation Chromatin Assembly Mitotic G1 DNA Damage Checkpoint T Cell Differentiation In Thymus Regulation Of Tissue Remodeling Cellular Response To UV Multicellular Organism Growth Cellular Response To Drug Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Response To Glucose Starvation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Entrainment Of Circadian Clock By Photoperiod Mitochondrial DNA Repair Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Response To Antibiotic Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Fibroblast Proliferation Circadian Behavior Bone Marrow Development Embryonic Organ Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Protein Stabilization Negative Regulation Of Helicase Activity RNA Polymerase II Preinitiation Complex Assembly Protein Tetramerization Neuron Apoptotic Process Negative Regulation Of Telomerase Activity Hematopoietic Stem Cell Differentiation Interferon-gamma-mediated Signaling Pathway Cardiac Septum Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein-containing Complex Assembly Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Thymocyte Apoptotic Process Necroptotic Process Positive Regulation Of Cell Cycle Arrest Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To UV-C Mitotic Cell Cycle Arrest Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Actinomycin D Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Cell Aging Replicative Senescence Oxidative Stress-induced Premature Senescence Intrinsic Apoptotic Signaling Pathway Oligodendrocyte Apoptotic Process Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of Pentose-phosphate Shunt Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To DNA Damage Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cellular Senescence Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Osteoblast Differentiation Maternal Placenta Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Glycogen Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Glucose Metabolic Process Translation Regulation Of Translation Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Protein Import Into Nucleus Nitric Oxide Biosynthetic Process Activation-induced Cell Death Of T Cells Inflammatory Response Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Germ Cell Development Aging Cell Proliferation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Apoptotic Mitochondrial Changes Carbohydrate Transport Response To Heat Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Positive Regulation Of Fibroblast Migration Positive Regulation Of Sodium Ion Transport Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Endopeptidase Activity Regulation Of Neuron Projection Development Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Macroautophagy Phosphorylation Protein Ubiquitination Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cytokine-mediated Signaling Pathway Spinal Cord Development Cell Projection Organization Cell Differentiation Protein Catabolic Process Hyaluronan Metabolic Process Positive Regulation Of Cell Growth Regulation Of Cell Migration Endocrine Pancreas Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Regulation Of Myelination Lipopolysaccharide-mediated Signaling Pathway TOR Signaling Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Protein Binding Response To Food Activation Of Protein Kinase B Activity Positive Regulation Of Cellular Protein Metabolic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Response To Fluid Shear Stress Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Interleukin-18-mediated Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus NIK/NF-kappaB Signaling Glucose Homeostasis Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Anoikis Regulation Of MRNA Stability Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Cell Size Negative Regulation Of Proteolysis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasoconstriction Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Import Negative Regulation Of JNK Cascade Positive Regulation Of Organ Growth Protein Autophosphorylation Positive Regulation Of Lipid Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of DNA-binding Transcription Factor Activity Striated Muscle Cell Differentiation Cofactor Metabolic Process Negative Regulation Of Protein Kinase B Signaling Excitatory Postsynaptic Potential Response To Growth Hormone Mammary Gland Epithelial Cell Differentiation Glycogen Cell Differentiation Involved In Embryonic Placenta Development Labyrinthine Layer Blood Vessel Development Response To UV-A Cellular Response To Mechanical Stimulus Cellular Response To Cadmium Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Negative Regulation Of Protein Serine/threonine Kinase Activity Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Execution Phase Of Apoptosis Negative Regulation Of Protein Kinase Activity By Protein Phosphorylation Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Neuron Death Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of I-kappaB Phosphorylation Cellular Response To Nerve Growth Factor Stimulus Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Protein Localization To Cell Surface Negative Regulation Of Lymphocyte Migration Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Activation of NOXA and translocation to mitochondria Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence DNA Damage/Telomere Stress Induced Senescence SUMOylation of transcription factors Autodegradation of the E3 ubiquitin ligase COP1 Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Metabolic Genes Ub-specific processing proteases Ovarian tumor domain proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Expression Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation G2/M DNA damage checkpoint G2/M Checkpoints Stabilization of p53 Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional Regulation by VENTX RUNX3 regulates CDKN1A transcription Regulation of PTEN gene transcription Regulation of PTEN gene transcription Factors involved in megakaryocyte development and platelet production	Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation mTOR signalling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network eNOS activation AKT-mediated inactivation of FOXO1A Integrin signaling Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling CTLA4 inhibitory signaling G beta:gamma signalling through PI3Kgamma Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity Extra-nuclear estrogen signaling Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs		Acetylsalicylic acid Zinc Triethyl Phosphate AZD 3355 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine	ATP Arsenic trioxide Genistein Inositol 1,3,4,5-Tetrakisphosphate Resveratrol N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
Diseases		Osteosarcoma Adrenal carcinoma Thyroid cancer Breast cancer Basal cell carcinoma Malignant melanoma Pancreatic cancer Gastric cancer Malignant pleural mesothelioma Non-small cell lung cancer Esophageal cancer Oral cancer Multiple myeloma Small cell lung cancer Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL) Glioma Squamous cell carcinoma Kaposi's sarcoma Cholangiocarcinoma Gallbladder cancer Cancer of the anal canal Hepatocellular carcinoma Choriocarcinoma Vulvar cancer Choroid plexus papilloma Burkitt lymphoma Adult T-cell leukemia Hairy-cell leukemia Bladder cancer Chronic lymphocytic leukemia (CLL) Penile cancer Endometrial Cancer Ovarian cancer Colorectal cancer Laryngeal cancer Chronic myeloid leukemia (CML)	PTEN hamartoma tumor syndrome (PHTS), including: Cowden syndrome; Bannayan-Riley-Ruvalcaba syndrome; Proteus syndrome; Proteus-like syndrome
GWAS		Basal cell carcinoma ( 31174203 24403052 25855136 27539887 21946351) Birth weight ( 31043758) Cancer ( 28346444) Diastolic blood pressure ( 28135244 27841878 30578418) Esophageal squamous cell carcinoma ( 25129146) Glioblastoma ( 28346443 29743610) Glioblastoma (age-stratified) ( 30152087) Glioma ( 28346443 29743610) Keratinocyte cancer (MTAG) ( 31174203) Mean corpuscular hemoglobin ( 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Non-glioblastoma glioma ( 28346443 29743610) Pulse pressure ( 28135244 27841878 30578418) Sex hormone levels ( 26014426) Sporadic neuroblastoma ( 28545128) Uterine fibroids ( 31249589 30194396 31649266)	Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401) HDL cholesterol ( 24097068 30275531 25961943) HDL cholesterol levels ( 28334899)
Interacting Genes		482 interacting genes: ABL1 ACKR3 ACTA1 AGT AIMP2 AKT1 ANK2 ANKRD2 ANTKMT ANXA2 ANXA3 APBB2 APEX1 APOH APPL1 APTX ARAF ARID1A ARID3A ARIH2 ARL3 ARNT ASH2L ATF3 ATM ATR ATRX ATXN3 AURKA AXIN1 BAG5 BAIAP2L1 BAK1 BANP BARD1 BAX BCCIP BCL2 BCL2L1 BCL2L12 BCL2L2 BCL6 BCR BLM BMP1 BRCA1 BRCA2 BRD7 BRF1 BTBD2 BTK C10orf90 CABLES1 CABLES2 CAPG CAPN1 CARM1 CBLC CCDC106 CCL18 CCNA2 CCNG1 CCNH CCT5 CD40LG CDC14A CDC14B CDC25C CDC42 CDK1 CDK2 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDKN1A CDKN2A CDKN2B CDKN2C CEBPZ CENPX CETP CHD3 CHEK1 CHEK2 CHUK COP1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 COX17 CR2 CRBN CREBBP CREBZF CRK CSNK1A1 CSNK1D CSNK2A1 CSNK2A2 CSNK2B CUL9 CXXC1 CYLD DAPK3 DAXX DCAF1 DDX20 DDX5 DGKZ DHCR24 DHFR DLEU1 DMTF1 DNAJB1 DNAJC7 DNMT3L DTL DVL2 E2F1 E4F1 EAF2 EEF2 EFEMP2 EGLN3 EGR1 EHMT1 EHMT2 EIF2AK2 EIF2S2 ELL ELL3 EP300 EPHA2 EPHA3 ERBB2 ERCC2 ERCC3 ERCC6 ERH ESR1 FBXO11 FBXO42 FCAMR FGFR4 FOXO3 FXYD6 FZR1 GADD45A GNL3 GPS1 GPS2 GPX2 GSK3B GSTM4 GTF2H1 GTF2H4 GYS2 HABP4 HDAC1 HDAC2 HDAC3 HECTD3 HECW1 HEY1 HIF1A HINFP HIPK1 HIPK2 HMGA2 HMGB1 HMGB2 HNF4A HNRNPUL1 HSP90AA1 HSP90AB1 HSP90B1 HSPA1A HSPA8 HSPA9 HSPB1 HTT HUWE1 IFI16 IKBKB ING1 ING4 ING5 IRF7 ITPK1 KAT2A KAT2B KAT5 KAT6A KAT7 KAT8 KDM1A KDM4D KIAA0087 KLF4 KLF6 KMT5A KPNA2 KPNA4 KPNB1 LACTB LAMA4 LAMTOR5 LATS2 LDB3 MAD2L1BP MAGEA2 MAGEB18 MAML1 MAP2K3 MAP2K5 MAP3K1 MAPK1 MAPK10 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK5 MDC1 MDH1 MDM2 MDM4 MED1 MED17 MED21 MEN1 MET MIF MNAT1 MNDA MPHOSPH6 MSL2 MSX1 MTA1 MTA2 MUC1 MUL1 MVP MYBBP1A MYC NABP1 NABP2 NAP1L1 NAT10 NCL NCOA1 NCOA2 NCOA3 NDN NEDD8 NEIL3 NF2 NFKBIA NFYA NFYB NGFR NMT1 NMT2 NOP53 NPM1 NQO1 NR0B2 NR3C1 NR4A1 NTHL1 OTUB1 OTUD5 PADI1 PAFAH1B3 PARP1 PBK PCDHA4 PDGFRA PDLIM7 PELI1 PELI2 PELP1 PER2 PHB PIAS1 PIAS2 PIAS4 PIN1 PLAGL1 PLCG2 PLK1 PLK3 PML PNP POLA1 PPA1 PPARGC1A PPIB PPM1D PPP1CA PPP1CC PPP1R13L PPP2CA PPP2R2B PPP4C PRIM1 PRKAB2 PRKCA PRKD1 PRKDC PRKN PRKRA PRMT1 PSMB3 PSMC5 PSMD11 PSMD4 PSME3 PTEN PTGS2 PTK2 PTTG1 RAB4A RAB7A RAD51 RANBP9 RAP1B RB1 RBBP6 RBCK1 RBPJ RCC1 RCHY1 RELA RING1 RNF125 RNF128 RNF38 RPA1 RPS3 RPS6KA1 RPS6KA2 RPS6KA3 RRM2 RRM2B RUNX3 S100A2 S100A4 S100A6 S100A8 S100B SAT1 SCAMP1 SERPINB9 SETD7 SFN SHISA5 SIN3A SIN3B SIRT1 SLC9A9 SMAD2 SMAD3 SMARCA4 SMARCB1 SMARCD1 SMN1 SMYD2 SNRPN SP1 SP3 SRC SRSF1 SSTR3 STAMBP STARD10 STAT6 STK11 STK4 STX5 SUB1 SULT1E1 SUMO1 SYVN1 TADA3 TAF1 TAF1A TAF1B TAF1C TAF9 TAF9B TBP TCF4 TEAD2 TEC TEP1 TFAP2A TFAP2C TFDP1 TFIP11 THAP12 THAP8 THRB TIAF1 TK1 TOP1 TOP1MT TOP2A TOP2B TOPORS TP53BP1 TP53BP2 TP53INP1 TP53RK TP63 TP73 TRIAP1 TRIM27 TRIM39 TSC22D1 TSG101 TTK TWIST1 TXN UBB UBE2A UBE2D1 UBE2I UBE2K UBE2L3 UBE2M UBE2N UBE2Q1 UBE2V2 UBE3A UFD1 UHRF1 UHRF2 UIMC1 USP11 USP21 USP24 USP28 USP3 USP42 USP49 USP7 UTP14A VRK1 WDR33 WDR5 WDR82 WRN WT1 WWOX XAF1 XPO1 XRCC6 YBX1 YWHAG YWHAZ YY1 YY2 ZBTB2 ZBTB49 ZCCHC10 ZHX1 ZIC3 ZMIZ2 ZNF148 ZNF24 ZNF302 ZNF679 ZNF839 ZNHIT1	308 interacting genes: ACAP1 ACAT2 AGAP2 AGR3 AHNAK AHSA1 AKT1S1 AKT2 AKTIP ALYREF APLP2 APOH APP APPL1 AR ARAF ARFIP2 ARNT ATXN1 AURKA BABAM1 BAD BCL10 BCL2L1 BCL2L11 BCL3 BECN1 BLVRA BPGM BRAF BRCA1 CAMKK1 CARHSP1 CASC3 CASP3 CASP9 CBLC CCDC88A CCND2 CCNE1 CCNF CCNI CD44 CDC37 CDK4 CDK6 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CEP57L1 CEP76 CHEK1 CHUK CLASP2 CLIP3 CLK2 CNOT9 CREB1 CREBBP CSNK2A1 CTDSP2 CTNNB1 CYLD DAB2IP DCTN1 DLC1 DNAJB1 DNMT1 EEF1G EIF4EBP1 EMSY ENO2 EP300 EPHA2 EPSTI1 ERBB2 ESR1 ESR2 EZH2 FAF1 FANCA FANCI FASN FBXO31 FGFR4 FOXO1 FOXO3 FOXO4 FUS FZR1 GAB2 GATA1 GATA2 GET4 GFAP GJA1 GLIS2 GRB10 GRIN2A GSK3A GSK3B H2BC21 H2BC3 HIF1A HMOX1 HSP90AA1 HSP90AB1 HSPB1 HTT IKBKB IL13RA2 IL24 ILK IMPDH2 IRAK1 IRS1 ITGB3 ITPR1 ITPR3 IWS1 JADE1 KANK1 KAT2A KAT2B KAT6A KDELR2 KLHL3 KMT2D KRT10 LANCL2 LATS2 LRRK2 LTB4R2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP3K11 MAP3K5 MAP3K8 MAPK14 MAPK8 MAPK8IP1 MAPK9 MAPKAP1 MAPKAPK2 MAPT MATK MDM2 MDM4 METTL1 MRC2 MS4A2 MSH2 MST1R MTA3 MTCP1 MTOR MTUS2 MUL1 MXD1 MYC NCF2 NCOA4 NCOR2 NF1 NF2 NGB NOL4 NOS3 NOTCH1 NR4A1 NSD3 OSGIN1 PAK1 PDE3A PDE3B PDGFRA PDHB PDK1 PDK2 PDPK1 PEA15 PFKFB1 PFKFB2 PFKP PHB2 PI4K2B PIAS1 PIAS2 PICK1 PIK3CA PIK3R1 PIP5K1C PKN2 PLCG1 PLEKHO1 PLP1 PLXNA1 PPARGC1B PPL PPM1A PPP2CA PPP2R1A PRG2 PRKCB PRKCQ PRKCZ PRKDC PSMC5 PTEN PTGDS PTPA PTPN1 PTPN11 PTPN3 PYGO2 RAB3D RAC1 RAF1 RARA RASL10B RASSF1 RGCC RHEBL1 RNF11 RNF115 RPS6KB1 S100A14 S1PR1 SERPINB5 SETDB1 SH2B2 SH3RF1 SIRPA SIRT1 SIRT6 SKI SKP2 SLC9A3R1 SMAD2 SMAD3 SMAD4 SMAD7 SMARCB1 SMARCC1 SNCA SNCB SORBS2 SOX2 SOX4 SP1 SP3 SRC SRPK2 SRR SSH1 ST14 STAT1 STK11 STK3 STK4 SULT4A1 SUPT6H SYTL1 TBC1D4 TBC1D7 TCL1A TCL1B TCL6 TEAD2 TERF2IP TERT TFF1 THEM4 THRSP TMCC2 TNFRSF1A TNFSF11 TNK2 TOPBP1 TP53 TRIB3 TRIM13 TRMT2B TSC1 TSC2 TTC3 UBE2S UCHL1 USP4 UXS1 VEGFA VHL VIM WNK1 WNK4 XIAP YAP1 YBX1 YWHAZ ZFP36L1 ZHX1 ZNF691 ZRANB1
Entrez ID		7157	207
HPRD ID		01859	01261
Ensembl ID		ENSG00000141510	ENSG00000142208
Uniprot IDs		A0A087WT22 A0A087WXZ1 A0A087X1Q1 H2EHT1 K7PPA8 P04637 Q53GA5	B0LPE5 B3KVH4 P31749
PDB IDs		1A1U 1AIE 1C26 1DT7 1GZH 1H26 1HS5 1JSP 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAK 1SAL 1TSR 1TUP 1UOL 1XQH 1YC5 1YCQ 1YCR 1YCS 2AC0 2ADY 2AHI 2ATA 2B3G 2BIM 2BIN 2BIO 2BIP 2BIQ 2F1X 2FEJ 2FOJ 2FOO 2GS0 2H1L 2H2D 2H2F 2H4F 2H4H 2H4J 2H59 2J0Z 2J10 2J11 2J1W 2J1X 2J1Y 2J1Z 2J20 2J21 2K8F 2L14 2LY4 2MEJ 2MWO 2MWP 2MWY 2MZD 2OCJ 2PCX 2RUK 2VUK 2WGX 2X0U 2X0V 2X0W 2XWR 2YBG 2YDR 2Z5S 2Z5T 3D05 3D06 3D07 3D08 3D09 3D0A 3DAB 3DAC 3IGK 3IGL 3KMD 3KZ8 3LW1 3OQ5 3PDH 3Q01 3Q05 3Q06 3SAK 3TG5 3TS8 3ZME 4AGL 4AGM 4AGN 4AGO 4AGP 4AGQ 4BUZ 4BV2 4HFZ 4HJE 4IBQ 4IBS 4IBT 4IBU 4IBV 4IBW 4IBY 4IBZ 4IJT 4KVP 4LO9 4LOE 4LOF 4MZI 4MZR 4QO1 4RP6 4RP7 4X34 4XR8 4ZZJ 5A7B 5AB9 5ABA 5AOI 5AOJ 5AOK 5AOL 5AOM 5BUA 5ECG 5G4M 5G4N 5G4O 5HOU 5HP0 5HPD 5LAP 5LGY 5MCT 5MCU 5MCV 5MCW 5MF7 5MG7 5MHC 5MOC 5O1A 5O1B 5O1C 5O1D 5O1E 5O1F 5O1G 5O1H 5O1I 5OL0 5UN8 5XZC 6FF9 6FJ5 6GGA 6GGB 6GGC 6GGD 6GGE 6GGF 6RZ3	1H10 1UNP 1UNQ 1UNR 2UVM 2UZR 2UZS 3CQU 3CQW 3MV5 3MVH 3O96 3OCB 3OW4 3QKK 3QKL 3QKM 4EJN 4EKK 4EKL 4GV1 5KCV 6BUU 6CCY 6HHF 6HHG 6HHH 6HHI 6HHJ 6NPZ 6S9W 6S9X
Enriched GO Terms of Interacting Partners?
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