TRIM21 and CASP8AP2

Number of citations of the paper that reports this interaction (PubMedID 20697732)
4

Data Source:
BioGRID (two hybrid)

		TRIM21	CASP8AP2
Description		tripartite motif containing 21	caspase 8 associated protein 2
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol SCF Ubiquitin Ligase Complex Cytoplasmic Vesicle Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion PML Body
	Molecular Function	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Identical Protein Binding	DNA Binding Transcription Corepressor Activity Death Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Peptidase Activator Activity Involved In Apoptotic Process SUMO Polymer Binding
	Biological Process	Protein Polyubiquitination Protein Monoubiquitination Cell Cycle Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Response To Interferon-gamma Innate Immune Response Positive Regulation Of Cell Cycle Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Protein Deubiquitination Negative Regulation Of Viral Release From Host Cell	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Fas Signaling Pathway Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling Antigen processing: Ubiquitination & Proteasome degradation	SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		Lung cancer ( 28604730)	Estimated glomerular filtration rate in non-diabetics ( 31451708) Major depressive disorder ( 29317602)
Interacting Genes		52 interacting genes: APC CALR CASP8AP2 CDC34 CUL1 DAXX DCP2 DZIP3 FADD FBXW11 GABARAP GABARAPL1 GABARAPL2 GRAP HLA-DRB1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NIF3L1 PFKP RBCK1 RNF111 RO60 SKP2 SQSTM1 TBK1 TRIM27 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2E1 UBE2H UBE2I UBE2L3 UBE2N UBE2V2 UBE2W USP15 USP2 USP4 YWHAZ	17 interacting genes: CALM1 CASP10 CASP8 CREBBP CREM CTBP2 FADD FAS GLUL MX1 NR3C2 PML SP100 SREBF2 TRAF2 TRIM21 UBE2I
Entrez ID		6737	9994
HPRD ID		00170	06048
Ensembl ID		ENSG00000132109	ENSG00000118412
Uniprot IDs		P19474	Q9UKL3
PDB IDs		2IWG 5JPX 5OLM 6FGA 6S53	2LR8 6ANO 6AOZ 6AP0
Enriched GO Terms of Interacting Partners?
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