SNAP25 and SYT1

Number of citations of the paper that reports this interaction (PubMedID 12062043)
88

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro)

		SNAP25	SYT1
Description		synaptosome associated protein 25	synaptotagmin 1
Image
GO Annotations	Cellular Component	Photoreceptor Inner Segment Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Cell Junction Growth Cone BLOC-1 Complex SNARE Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Vesicle Specific Granule Membrane Somatodendritic Compartment Presynaptic Membrane Neuron Projection Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Tertiary Granule Membrane Postsynapse Glutamatergic Synapse	Cytoplasm Golgi Apparatus Plasma Membrane Synaptic Vesicle Cell Junction Integral Component Of Synaptic Vesicle Membrane Axon Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Chromaffin Granule Membrane Presynaptic Membrane Neuron Projection Neuron Projection Terminus Excitatory Synapse Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane Exocytic Vesicle Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse
	Molecular Function	Voltage-gated Potassium Channel Activity SNAP Receptor Activity Protein Binding Syntaxin-1 Binding Syntaxin Binding Calcium-dependent Protein Binding	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding Syntaxin-1 Binding Syntaxin Binding Clathrin Binding Syntaxin-3 Binding Identical Protein Binding Protein Heterodimerization Activity Calcium-dependent Protein Binding Low-density Lipoprotein Particle Receptor Binding Calcium Ion Sensor Activity
	Biological Process	Neurotransmitter Uptake Exocytosis Vesicle Fusion Chemical Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Associative Learning Regulation Of Neuron Projection Development Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Neutrophil Degranulation Regulation Of Insulin Secretion Long-term Synaptic Potentiation Potassium Ion Transmembrane Transport Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Neurotransmitter Receptor Internalization	Detection Of Calcium Ion Chemical Synaptic Transmission Neurotransmitter Secretion Brain Development Glutamate Secretion Regulation Of Dopamine Secretion Synaptic Vesicle Exocytosis Vesicle-mediated Transport Calcium Ion Regulated Exocytosis Regulation Of Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Dopamine Secretion Vesicle Docking Synaptic Vesicle Endocytosis Calcium Ion-regulated Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Transmission Protein Heterooligomerization Regulation Of Synaptic Transmission, Glutamatergic Membrane Organization Spontaneous Neurotransmitter Secretion Cellular Response To Calcium Ion Synchronous Neurotransmitter Secretion Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium-dependent Activation Of Synaptic Vesicle Fusion Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Regulated Secretory Pathway Positive Regulation Of Dendrite Extension
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type A (BoNT/A) Toxicity of botulinum toxin type C (BoNT/C) Toxicity of botulinum toxin type E (BoNT/E) Neutrophil degranulation GABA synthesis, release, reuptake and degradation	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (BoNT/B) Toxicity of botulinum toxin type G (BoNT/G) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis GABA synthesis, release, reuptake and degradation
Drugs		Botulinum Toxin Type A
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603)	Chloride levels ( 29403010) Estimated glomerular filtration rate ( 31217584) General cognitive ability ( 29844566) Hand grip strength ( 29313844) Intelligence (MTAG) ( 29326435) Lysophosphatidylcholine levels ( 31551469) Obesity-related traits ( 23251661) Pulse pressure ( 30578418) QRS duration ( 31251759) Sodium levels ( 29403010) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653)
Interacting Genes		35 interacting genes: APP CENPF CPLX1 DNM1 FBXO7 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 VAMP2 VAMP7 VAMP8 WASHC3 ZDHHC17	30 interacting genes: CACNA1A CACNB3 CACNB4 CALM1 FGF1 GOLM1 IKBKG IRF3 NEDD4 NR1H3 NR3C1 NRXN1 PPARG RACK1 RBM14 RIMS1 S100A13 SIN3A SMAD2 SNAP25 STON2 STX1A STX2 STX3 STX4 SV2B SYNCRIP SYT4 TFAP2A ZDHHC17
Entrez ID		6616	6857
HPRD ID		02637	01710
Ensembl ID		ENSG00000132639	ENSG00000067715
Uniprot IDs		P60880	A0A024RBE9 J3KQA0 P21579
PDB IDs		1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J	2K45 2K4A 2K8M 2KI6 2LHA 2N1T 2R83 3F00 3F01 3F04 3F05 4ISQ 4V11 6G5F 6G5K
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?