SUMO3 and TDP2

Number of citations of the paper that reports this interaction (PubMedID 16524884)
197

Data Source:
BioGRID (pull down)

		SUMO3	TDP2
Description		small ubiquitin like modifier 3	tyrosyl-DNA phosphodiesterase 2
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GO Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body	Nucleus Nucleoplasm Nucleolus Cytoplasm Aggresome Nuclear Body PML Body
	Molecular Function	Protein Binding Enzyme Binding	Magnesium Ion Binding Single-stranded DNA Binding Transcription Corepressor Activity Nuclease Activity Protein Binding Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity
	Biological Process	Protein Sumoylation Negative Regulation Of DNA Binding	Double-strand Break Repair Cell Surface Receptor Signaling Pathway Viral Process Neuron Development Nucleic Acid Phosphodiester Bond Hydrolysis Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER	Nonhomologous End-Joining (NHEJ)
Drugs
Diseases
GWAS		Delirium ( 29631748)	Colorectal or endometrial cancer ( 26621817)
Interacting Genes		47 interacting genes: ANXA7 BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 DAXX EGLN3 FOS HIPK2 HSF1 HSF2 JUN KALRN MAPKAPK3 PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 RNF111 RNF8 SAE1 SENP1 SENP2 SENP5 SMN1 SOX10 SOX6 SP100 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USP25 USPL1 VIM WWTR1 YAP1	34 interacting genes: AKAP9 ATP5MC2 ATXN1 BTBD2 C2orf88 CD40 DLX3 DVL2 EPS8 ETS1 ETS2 FLI1 GOLGA2 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TFIP11 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I WBP2
Entrez ID		6612	51567
HPRD ID		03754	05771
Ensembl ID		ENSG00000184900	ENSG00000111802
Uniprot IDs		P55854	A0A384MDM5 O95551
PDB IDs		1U4A 2IO1 2MP2 6K5R 6NNQ	5INO 5J3P 5J3S
Enriched GO Terms of Interacting Partners?
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