SMAD7 and WWP2

Number of citations of the paper that reports this interaction (PubMedID 22773947)
41

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		SMAD7	WWP2
Description		SMAD family member 7	WW domain containing E3 ubiquitin protein ligase 2
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GO Annotations	Cellular Component	Nuclear Chromatin Fibrillar Center Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Centrosome Cytosol Plasma Membrane Adherens Junction Catenin Complex Protein-containing Complex	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Collagen Binding Beta-catenin Binding Transforming Growth Factor Beta Receptor, Inhibitory Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Activin Binding I-SMAD Binding	RNA Polymerase II Transcription Factor Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Negative Regulation Of T Cell Cytokine Production Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Transcription By Competitive Promoter Binding Protein Deubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Ossification Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Peptidyl-serine Phosphorylation Adherens Junction Assembly Response To Laminar Fluid Shear Stress Cellular Protein-containing Complex Localization Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Artery Morphogenesis Protein Stabilization Negative Regulation Of Ubiquitin-protein Transferase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Ventricular Septum Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Chondrocyte Hypertrophy Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T-helper 17 Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Extracellular Transport Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Viral Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription UCH proteinases Ub-specific processing proteases	Regulation of PTEN stability and activity NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Colorectal cancer ( 25990418 18372901 18372905 30529582 21761138 17934461 26151821 29228715 30104761 24836286 29471430 24448986 23266556) Colorectal cancer or advanced adenoma ( 30510241) Creatinine levels ( 29403010) Dental caries ( 23064961) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Inflammatory bowel disease ( 23128233) Parental longevity (at least one long-lived parent) ( 27816938) Red blood cell count ( 27863252)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 28552196 31562340) IgE levels ( 23146381) Knee osteoarthritis ( 30374069) Lung function (FVC) ( 30804560) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Menarche (age at onset) ( 25231870) Plantar fascial disorders ( 29534260) Pulse pressure ( 30578418) Smoking behaviour (cigarette pack-years) ( 30679032) Triglycerides ( 30275531)
Interacting Genes		59 interacting genes: ACVR1B AKT1 ASH1L AXIN1 AXIN2 BMPR1B CBL CTNNB1 CXXC5 DVL1 EP300 ERBIN HAT1 HEYL KDM2A MAP2K3 MAP2K6 MAP3K7 MAPK14 MBD1 MRTFB MYOD1 NEDD4L OTUD1 PARD3 PIAS1 PIAS4 RLIM RNF111 SASH3 SETD7 SIRT1 SMAD2 SMAD3 SMAD4 SMAD6 SMURF1 SMURF2 SOX13 SOX5 SOX7 STAMBP STAMBPL1 STRAP TAB1 TGFB1I1 TGFBR1 TGFBR2 TTF1 TTF2 UBE2L3 UCHL5 WWP2 XRCC6 YAP1 ZBTB11 ZBTB44 ZEB1 ZNF107	60 interacting genes: ANKRD44 ARRDC1 ATN1 CDC34 CLCN5 CPSF6 DAG1 DIDO1 EGR2 EWSR1 FAM189A2 FBXL18 GRAP2 HNRNPUL1 IL2RG IL6R LGALS9B NDFIP2 NUTF2 PAIP1 PDLIM7 PSMF1 PTEN RASA1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEC24D SF1 SFTPC SMAD3 SMAD7 SNRPC SPART TFAP2A TNK2 TP53BP2 TP73 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2J2 UBE2K UBE2L3 USP7 VASP VPS37C WBP1 WBP2 WIPF1 ZNF688
Entrez ID		4092	11060
HPRD ID		04241	03812
Ensembl ID		ENSG00000101665	ENSG00000198373
Uniprot IDs		B3KYA8 O15105	A0A024R711 B4DHF6 O00308
PDB IDs		2DJY 2KXQ 2LTV 2LTW 2LTX 2LTY 2LTZ	4Y07 5TJ7 5TJ8 5TJQ 6J1Z 6RSS
Enriched GO Terms of Interacting Partners?
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