LCP2 and LAT

Number of citations of the paper that reports this interaction (PubMedID 9489702)
311

Data Source:
HPRD (in vivo)

		LCP2	LAT
Description		lymphocyte cytosolic protein 2	linker for activation of T cells
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Mast Cell Granule Membrane Raft
	Molecular Function	Protein Binding	SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Mast Cell Activation Positive Regulation Of Protein Kinase Activity Cytokine Secretion T Cell Receptor Signaling Pathway	MAPK Cascade Adaptive Immune Response Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Signal Transduction Gene Expression Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Regulation Of T Cell Activation
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	GPVI-mediated activation cascade Generation of second messenger molecules
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)
Interacting Genes		43 interacting genes: APP BLNK CBL CD22 CLNK EGFR FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LARP1 LAT LCK LMNA LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70	33 interacting genes: CBL CD244 CD4 CD8A CREB3 EGFR FCGR1A FCGR2A FYN GAB2 GRAP GRAP2 GRB2 ITK KASH5 LCK LCP2 LMNA MAP4K1 PIK3R1 PLCG1 PLCG2 PTPN1 PTPN6 PTPRJ SGTA SH3BP2 SHB SLA SYK VAV1 ZAP70 ZHX2
Entrez ID		3937	27040
HPRD ID		03362	03832
Ensembl ID		ENSG00000043462	ENSG00000213658
Uniprot IDs		Q13094	A0A024QZD6 O43561
PDB IDs		1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?