IL16 and PPP1R12A

Number of citations of the paper that reports this interaction (PubMedID 12923170)
11

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		IL16	PPP1R12A
Description		interleukin 16	protein phosphatase 1 regulatory subunit 12A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Nuclear Speck Flemming Body	Kinetochore Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc A Band Contractile Fiber PTW/PP1 Phosphatase Complex
	Molecular Function	Cytokine Activity CD4 Receptor Binding	Enzyme Inhibitor Activity Protein Binding Phosphatase Regulator Activity Protein Kinase Binding 14-3-3 Protein Binding
	Biological Process	Immune Response Viral Process Cytokine-mediated Signaling Pathway Leukocyte Chemotaxis Induction Of Positive Chemotaxis Regulation Of Calcium Ion Transport	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Dephosphorylation Centrosome Cycle Signal Transduction Regulation Of Cell Adhesion Regulation Of Myosin-light-chain-phosphatase Activity Positive Regulation Of Myosin-light-chain-phosphatase Activity Cellular Response To Drug Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleocytoplasmic Transport Regulation Of Establishment Of Endothelial Barrier
Pathways		Other interleukin signaling	Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971) Brown vs. black hair color ( 30531825) Colorectal cancer (aspirin and/or NSAID use interaction) ( 25781442) Height ( 31562340) Inattentive symptoms ( 18821565) Interleukin-16 levels ( 27989323) Primary biliary cholangitis ( 28425483)	Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		31 interacting genes: CASP3 CD4 CDK1 CSNK2A1 CSNK2A2 DMRTB1 EFEMP2 GABPB1 GRIN2A GRIN2B GRIN2C GRIN2D HDAC3 KCNA3 KCND1 KCND2 KCNJ10 KCNJ15 KCNJ2 KCNJ4 KDM1A LNX2 PCSK6 PPP1R12A PPP1R12B PPP1R12C SUV39H1 TFIP11 TRIP6 USHBP1 ZNRD2	13 interacting genes: ATXN10 CDKN3 DMPK IL16 ILK KDM1A MPRIP PRKG1 RHOA ROCK1 ROCK2 SETD7 YWHAG
Entrez ID		3603	4659
HPRD ID		04329	03606
Ensembl ID		ENSG00000172349	ENSG00000058272
Uniprot IDs		Q14005 Q9UME6	B2RAH5 O14974
PDB IDs		1I16 1X6D 5FB8	2KJY 5HUZ
Enriched GO Terms of Interacting Partners?
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