HCK and RASA1

Number of citations of the paper that reports this interaction (PubMedID 7782336)
10

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo, in vitro)

		HCK	RASA1
Description		HCK proto-oncogene, Src family tyrosine kinase	RAS p21 protein activator 1
Image
GO Annotations	Cellular Component	Nucleoplasm Lysosome Golgi Apparatus Cytosol Actin Filament Plasma Membrane Caveola Focal Adhesion Transport Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Projection	Ruffle Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	Phosphotyrosine Residue Binding GTPase Activity GTPase Activator Activity Signaling Receptor Binding Protein Binding Potassium Channel Inhibitor Activity GTPase Binding
	Biological Process	Leukocyte Migration Involved In Immune Response Innate Immune Response-activating Signal Transduction Protein Phosphorylation Inflammatory Response Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Mesoderm Development Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Actin Filament Polymerization Lipopolysaccharide-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Leukocyte Degranulation Respiratory Burst After Phagocytosis Protein Autophosphorylation Regulation Of Defense Response To Virus By Virus Regulation Of Inflammatory Response Regulation Of Phagocytosis Regulation Of DNA-binding Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Podosome Assembly Positive Regulation Of Actin Cytoskeleton Reorganization	MAPK Cascade Mitotic Cytokinesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of RNA Metabolic Process
Pathways		Nef and signal transduction FCGR activation Regulation of signaling by CBL Regulation of signaling by CBL FLT3 Signaling FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis	Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs		1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Phosphonotyrosine Quercetin Bosutinib
Diseases			RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 23128233) Migraine ( 27322543)	Chronotype ( 30696823) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Openness ( 21173776) Prostate cancer aggressiveness ( 25939597) Type 2 diabetes ( 30297969)
Interacting Genes		78 interacting genes: ABL1 ABL2 ACTB ADAM15 AGK APP ARRB1 ASAP1 BCAR1 BCR BTK CBL CCR3 CD2AP CHST15 COMT CREBBP CSF2RB CSF3R CSK DNM2 DOK1 DOK2 EGFR ELMO1 ERBB3 EVL FASLG FCGR1A FCGR2A FHL2 GOPC GRB14 HNRNPK IL6ST INPP5D IRF2BPL KHDRBS1 KIT KRT40 KRTAP10-9 LCP2 LETMD1 LMNA MAP4K5 MDM2 MTUS2 NGEF NOTCH2NLA PAK2 PECAM1 PIK3CB PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 RAPGEF1 RASA1 RASA3 RPL10 SF3B3 SH3BP1 SH3KBP1 SKAP2 SOS1 SPRR2A STAT3 TNK2 TP73 TRPV4 TSG101 UNC119 VAV1 WAS WDCP WIPF1 WNT2	75 interacting genes: ABL1 AFAP1L2 ANXA6 APP ARHGAP1 ARHGAP5 AURKB BBS10 BCR BIRC5 CASP3 CASP7 CAV2 CD5 CSF1R CSK DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES FGFR1 G3BP1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 NCK1 NTRK1 OLIG1 PAG1 PDE6D PDGFRB PIK3R1 PTK2B PTPRC PXN RAB5A RACK1 RAP1A SERPINA4 SHC1 SLC9A2 SOCS3 SPSB1 SRC STAU1 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579
Entrez ID		3055	5921
HPRD ID		00796	00745
Ensembl ID		ENSG00000101336	ENSG00000145715
Uniprot IDs		A8K4G3 P08631	P20936 Q59GK3
PDB IDs		1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 4LUD 4LUE 4ORZ 4U5W 5H09 5H0B 5H0E 5H0G 5H0H 5HCK 5NUH 5ZJ6	1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS
Enriched GO Terms of Interacting Partners?
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