GRIN1 and CAMK2A

Number of citations of the paper that reports this interaction (PubMedID 10862698)
341

Data Source:
HPRD (in vivo)

		GRIN1	CAMK2A
Description		glutamate ionotropic receptor NMDA type subunit 1	calcium/calmodulin dependent protein kinase II alpha
Image
GO Annotations	Cellular Component	Cell Cytoplasm Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density NMDA Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Synaptic Cleft Terminal Bouton Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Synaptic Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Cell Junction Endocytic Vesicle Membrane Neuron Projection Dendritic Spine
	Molecular Function	Amyloid-beta Binding NMDA Glutamate Receptor Activity Signaling Receptor Binding Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Ligand-gated Ion Channel Activity Glycine Binding Glutamate Binding Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Neurotransmitter Binding Protein-containing Complex Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Glutamate Receptor Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	MAPK Cascade Conditioned Taste Aversion Suckling Behavior Response To Amphetamine Cation Transport Chemical Synaptic Transmission Brain Development Long-term Memory Adult Locomotory Behavior Olfactory Learning Visual Learning Positive Regulation Of Calcium Ion Transport Into Cytosol Propylene Metabolic Process Sensory Perception Of Pain Calcium-mediated Signaling Pons Maturation Cerebral Cortex Development Social Behavior Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Response To Morphine Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Dendrite Morphogenesis Regulation Of Axonogenesis Protein Heterotetramerization Regulation Of Synapse Assembly Calcium Ion Homeostasis Excitatory Postsynaptic Potential Prepulse Inhibition Male Mating Behavior Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Protein Localization To Postsynaptic Membrane Cellular Response To Amyloid-beta Response To Glycine Regulation Of NMDA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Cysteine-type Endopeptidase Activity	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Wnt Signaling Pathway, Calcium Modulating Pathway Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Angiotensin-activated Signaling Pathway Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Dendritic Spine Development Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Peptidyl-threonine Autophosphorylation Regulation Of Neuron Migration
Pathways		EPHB-mediated forward signaling EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Ca2+ pathway Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants
Drugs		Glutamic Acid Atomoxetine Pentobarbital Secobarbital Pethidine Acamprosate Gabapentin Memantine Orphenadrine Phenobarbital Prasterone Dcka, 5,7-Dichlorokynurenic Acid D-Serine Cycloleucine Milnacipran CNS-5161 Acetylcysteine Ketobemidone Gavestinel Agmatine Ifenprodil Magnesium acetate tetrahydrate Magnesium carbonate Fluciclovine (18F)	Hexatantalum Dodecabromide 1,4-Dithiothreitol (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}
Diseases
GWAS		Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)	Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Ulcerative colitis ( 28067908)
Interacting Genes		54 interacting genes: ACTN2 AKAP9 APP CALM1 CAMK2A CAMK2G CANX CDH2 CIT CLTC CTNNB1 DLG2 DLG3 DLG4 DLGAP4 DNM1 DRD1 DUSP4 EPHB2 EPHB4 FUS FYN GRIN2A GRIN2B GRIN2D GRIN3A HNRNPU HRAS HSPA1A INA LNX1 LRP8 MAP2 MAP2K2 MYH9 NANOS1 NEFL NF1 PLAT PLCG1 PPP2R1A PPP2R2A PRKCA PRKCB PRKCE PRKCG RAP2A RPS6KA3 SP3 SPTAN1 SYNGAP1 TJP1 TRAF3 TUBA4B	40 interacting genes: ACTN1 ACTN2 ACTN4 ATF1 ATP2A2 CAMK2N2 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DLG1 EGFR ETS1 GFAP GRIN1 GRIN2A GRIN2B HSF1 ITGA2B ITGB1BP1 ITPKA KRT18 LRRC7 MAPT MPDZ NOS1 PDC PPM1F PSMC5 PTTG1 RCHY1 RIMS1 SMAD2 SQSTM1 SRF SYNGAP1 TANC1 YWHAB
Entrez ID		2902	815
HPRD ID		15926	06532
Ensembl ID		ENSG00000176884	ENSG00000070808
Uniprot IDs		Q05586 Q59GW0 Q5VSF9	A8K161 Q7LDD5 Q8IWE0 Q9UQM7
PDB IDs		2HQW 2NR1 3BYA 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA 6IRA 6IRF 6IRG 6IRH	2VZ6 3SOA 5IG3 6OF8
Enriched GO Terms of Interacting Partners?
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