CORO1C and LMO2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CORO1C	LMO2
Description		coronin 1C	LIM domain only 2
Image		No pdb structure
GO Annotations	Cellular Component	Focal Adhesion Cell Cortex Endosome Membrane Actin Cytoskeleton Lateral Plasma Membrane Flotillin Complex Sarcomere Lamellipodium Vesicle Ruffle Membrane Sarcolemma Synapse	Nucleoplasm Transcription Factor Complex
	Molecular Function	Protein Binding Rac GTPase Binding Actin Filament Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding BHLH Transcription Factor Binding Metal Ion Binding Cofactor Binding E-box Binding
	Biological Process	Neural Crest Cell Migration Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Phagocytosis Actin Filament Organization Signal Transduction Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial Cell Migration Regulation Of Fibroblast Migration Endosomal Transport Cell Migration Ventricular System Development Corpus Callosum Development Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Establishment Of Protein Localization Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Membrane Fission Activation Of GTPase Activity Endosome Membrane Tubulation Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Ruffle Assembly Positive Regulation Of Lamellipodium Morphogenesis	Multicellular Organism Development MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Thyroid Hormone Stimulus Regulation Of Hematopoietic Stem Cell Differentiation
Pathways			RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Acne (severe) ( 24927181) Coronary artery disease and LDL cholesterol levels (multivariate analysis) ( 30525989) Low high density lipoprotein cholesterol levels ( 26879886) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)	Cognitive performance ( 19734545) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 27863252)
Interacting Genes		2 interacting genes: LMO2 RAC1	97 interacting genes: ABI2 ADAMTSL4 AFDN AGTRAP AIMP2 ALDH6A1 AXIN1 BANP BEX2 BLZF1 C1orf94 CALCOCO2 CBY2 CCDC33 CDC25A CDC5L CDX4 CLHC1 CMTM5 CORO1A CORO1C DAZAP2 DBF4B DDIT3 DRAP1 EHMT2 ELF2 ERBIN FHL3 GATA1 GATA2 GATA3 GFAP GOLGA2 GRB2 HNRNPC HNRNPM HOOK1 IFT43 IHO1 IKZF3 ISL1 KANK2 KDM5A KIF3B KRT15 KRT40 KRTAP10-7 LDB1 LYL1 LZTS2 MAGEA8 MAPRE1 MAPRE2 MAPRE3 MBIP MRFAP1L1 MTUS2 N4BP2L2 NCAPH2 NHLH1 NIF3L1 NOTCH2NLA NUP62 NUTM1 PDE9A PHC2 PRKG1 RBBP8 REL RELA RINT1 RLIM ROCK1 SAXO1 SKP1 SMAD2 SOX5 SP1 SSX2IP STAT1 STAT3 STIP1 TAL1 TAL2 TFPT TLE5 TLX3 TRIM23 TRIM54 TRIP6 TSC22D4 TUFT1 UBA6 UBE2I ZFP64 ZNF24
Entrez ID		23603	4005
HPRD ID		09244	01586
Ensembl ID		ENSG00000110880	ENSG00000135363
Uniprot IDs		A0A024RBI5 Q9ULV4	P25791
PDB IDs			2XJY 2XJZ 2YPA 4KFZ
Enriched GO Terms of Interacting Partners?
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