CARD8 and CARD18

Number of citations of the paper that reports this interaction (PubMedID 11821383)
50

Data Source:
HPRD (in vivo, in vitro)

		CARD8	CARD18
Description		caspase recruitment domain family member 8	caspase recruitment domain family member 18
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Inflammasome Complex NLRP3 Inflammasome Complex	Protein-containing Complex
	Molecular Function	Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process NACHT Domain Binding Protein Homodimerization Activity CARD Domain Binding	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding CARD Domain Binding Caspase Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Secretion Inhibition Of Cysteine-type Endopeptidase Activity	Inflammatory Response Negative Regulation Of Protein Binding Regulation Of Apoptotic Process Negative Regulation Of Interleukin-1 Beta Secretion Inhibition Of Cysteine-type Endopeptidase Activity
Pathways		Formation of apoptosome Regulation of the apoptosome activity
Drugs
Diseases
GWAS
Interacting Genes		9 interacting genes: CARD16 CARD18 CASP1 CASP9 FHL2 IKBKG MTDH NLRP2 NLRP3	2 interacting genes: CARD17 CARD8
Entrez ID		22900	59082
HPRD ID		16425	16099
Ensembl ID		ENSG00000105483	ENSG00000255501
Uniprot IDs		A0A024QZD3 E5RFV9 Q9Y2G2	P57730
PDB IDs		4IKM	1DGN
Enriched GO Terms of Interacting Partners?
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