TRIM40 and IFIH1

Number of citations of the paper that reports this interaction (PubMedID 29117565)
14

Data Source:
BioGRID (enzymatic study)

		TRIM40	IFIH1
Description		tripartite motif containing 40	interferon induced with helicase C domain 1
Image		No pdb structure
GO Annotations	Cellular Component	IkappaB Kinase Complex	Nucleus Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding	DNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Negative Regulation Of Cell Growth Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Protein Catabolic Process Protein Neddylation Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of NIK/NF-kappaB Signaling	Detection Of Virus Response To Virus Viral Process Protein Deubiquitination Protein Sumoylation Negative Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of Type III Interferon Production Positive Regulation Of Interferon-beta Secretion Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus MDA-5 Signaling Pathway Innate Immune Response Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Positive Regulation Of Interferon-alpha Secretion Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Interleukin-6 Secretion
Pathways			DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases			Type I diabetes mellitus
GWAS		Anger ( 24489884) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Mean platelet volume ( 27863252) Neuroticism ( 29255261) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Immunoglobulin A ( 20694011) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Psoriasis ( 25903422 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 27399966 26502338 28714469 19838195) Type 1 diabetes ( 21829393 25751624 19430480 17554260) Vitiligo ( 27723757 22561518)
Interacting Genes		3 interacting genes: APP DDX58 IFIH1	5 interacting genes: APP TRIM40 TRIM65 USP3 ZCCHC3
Entrez ID		135644	64135
HPRD ID		15557	09507
Ensembl ID		ENSG00000204614	ENSG00000115267
Uniprot IDs		A0A1U9X8U1 Q6P9F5	Q9BYX4
PDB IDs			2RQB 3B6E 3GA3 4GL2
Enriched GO Terms of Interacting Partners?
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