LENS is a web-based tool to carry out interactome analysis of human genes. LENS takes one or two lists of genes and determines the network of protein-protein interactions
that connects them. LENS computes several statistics including associations of the genes in the interactome to diseases, drugs, pathways, and GWASs,
as well as, statistics of network connectivity of these genes compared against connectivity of randomly selected genes.
Sources of data for the network generation are direct (biophysical) interactions from HPRD and BioGRID. Genome-wide Association Studies (GWAS) data are obtained from NHGRI's Gwas Catalog.
Pathways are obtained from Reactome, drugs from DrugBank, and disease associations from OMIM.
The genes and interactions of the extracted network are shown with a visualization and are also connected to Wiki-Pi
, where their full annotations may be seen.