Schizophrenia - Wiki-Pi

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide
RARA and PHF8	retinoic acid receptor, alpha	PHD finger protein 8	Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters	Chromatin modifying enzymes Chromatin organization HDMs demethylate histones	Adapalene Acitretin Alitretinoin Tazarotene Etretinate Isotretinoin Tamibarotene
RASA1 and MAP4K4	RAS p21 protein activator (GTPase activating protein) 1	mitogen-activated protein kinase kinase kinase kinase 4	Signaling by PDGF EPHB-mediated forward signaling Axon guidance VEGFR2 mediated cell proliferation Signaling by VEGF Downstream signal transduction EPH-Ephrin signaling VEGFA-VEGFR2 Pathway	Oxidative Stress Induced Senescence Cellular Senescence
RBBP4 and HDAC4	retinoblastoma binding protein 4	histone deacetylase 4	Chromosome Maintenance Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Epigenetic regulation of gene expression G2/M Transition G0 and Early G1 PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Nucleosome assembly Oxidative Stress Induced Senescence Mitotic G2-G2/M phases Mitotic G1-G1/S phases Polo-like kinase mediated events	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
RBM4 and PTBP2	RNA binding motif protein 4	polypyrimidine tract binding protein 2
RCN2 and BAG6	reticulocalbin 2, EF-hand calcium binding domain	BCL2-associated athanogene 6
REG1B and BAG6	regenerating islet-derived 1 beta	BCL2-associated athanogene 6
RELA and TCF4	v-rel avian reticuloendotheliosis viral oncogene homolog A	transcription factor 4	Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB Transcriptional regulation of white adipocyte differentiation MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Regulated proteolysis of p75NTR Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TCR signaling Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Activation of NF-kappaB in B cells Interleukin-1 processing Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex	CDO in myogenesis Myogenesis
REV3L and HDAC4	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	histone deacetylase 4	Translesion synthesis by Pol zeta DNA Damage Bypass Translesion synthesis by DNA polymerases bypassing lesion on DNA template	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
ROBO1 and SLIT2	roundabout, axon guidance receptor, homolog 1 (Drosophila)	slit homolog 2 (Drosophila)	Inactivation of Cdc42 and Rac Role of Abl in Robo-Slit signaling Axon guidance Activation of Rac Regulation of Commissural axon pathfinding by Slit and Robo Netrin-1 signaling Signaling by Robo receptor	Inactivation of Cdc42 and Rac Role of Abl in Robo-Slit signaling Axon guidance Activation of Rac Regulation of Commissural axon pathfinding by Slit and Robo Netrin-1 signaling Signaling by Robo receptor
ROBO1 and TUBB3	roundabout, axon guidance receptor, homolog 1 (Drosophila)	tubulin, beta 3 class III	Inactivation of Cdc42 and Rac Role of Abl in Robo-Slit signaling Axon guidance Activation of Rac Regulation of Commissural axon pathfinding by Slit and Robo Netrin-1 signaling Signaling by Robo receptor	Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Orphan transporters Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System		Epothilone D Epothilone B Ixabepilone
ROBO1 and SRGAP2	roundabout, axon guidance receptor, homolog 1 (Drosophila)	SLIT-ROBO Rho GTPase activating protein 2	Inactivation of Cdc42 and Rac Role of Abl in Robo-Slit signaling Axon guidance Activation of Rac Regulation of Commissural axon pathfinding by Slit and Robo Netrin-1 signaling Signaling by Robo receptor	Inactivation of Cdc42 and Rac Rho GTPase cycle Axon guidance Signaling by Rho GTPases Signaling by Robo receptor
ROBO1 and SRGAP1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	SLIT-ROBO Rho GTPase activating protein 1	Inactivation of Cdc42 and Rac Role of Abl in Robo-Slit signaling Axon guidance Activation of Rac Regulation of Commissural axon pathfinding by Slit and Robo Netrin-1 signaling Signaling by Robo receptor	Inactivation of Cdc42 and Rac Rho GTPase cycle Axon guidance Signaling by Rho GTPases Signaling by Robo receptor
ROBO1 and SLIT1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	slit homolog 1 (Drosophila)	Inactivation of Cdc42 and Rac Role of Abl in Robo-Slit signaling Axon guidance Activation of Rac Regulation of Commissural axon pathfinding by Slit and Robo Netrin-1 signaling Signaling by Robo receptor	Axon guidance Netrin-1 signaling
ROBO2 and CENPU	roundabout, axon guidance receptor, homolog 2 (Drosophila)	centromere protein U	Axon guidance Regulation of Commissural axon pathfinding by Slit and Robo Signaling by Robo receptor	Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
ROBO2 and RPS6KA5	roundabout, axon guidance receptor, homolog 2 (Drosophila)	ribosomal protein S6 kinase, 90kDa, polypeptide 5	Axon guidance Regulation of Commissural axon pathfinding by Slit and Robo Signaling by Robo receptor	CREB phosphorylation Axon guidance Toll Like Receptor 7/8 (TLR7/8) Cascade CREB phosphorylation L1CAM interactions Recycling pathway of L1 Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets Toll Like Receptor 3 (TLR3) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
ROBO2 and RDH11	roundabout, axon guidance receptor, homolog 2 (Drosophila)	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	Axon guidance Regulation of Commissural axon pathfinding by Slit and Robo Signaling by Robo receptor	Visual phototransduction Signaling by Retinoic Acid The canonical retinoid cycle in rods (twilight vision) Diseases associated with visual transduction RA biosynthesis pathway Retinoid metabolism and transport
ROBO2 and SLIT2	roundabout, axon guidance receptor, homolog 2 (Drosophila)	slit homolog 2 (Drosophila)	Axon guidance Regulation of Commissural axon pathfinding by Slit and Robo Signaling by Robo receptor	Inactivation of Cdc42 and Rac Role of Abl in Robo-Slit signaling Axon guidance Activation of Rac Regulation of Commissural axon pathfinding by Slit and Robo Netrin-1 signaling Signaling by Robo receptor
ROBO2 and SSRP1	roundabout, axon guidance receptor, homolog 2 (Drosophila)	structure specific recognition protein 1	Axon guidance Regulation of Commissural axon pathfinding by Slit and Robo Signaling by Robo receptor	Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
ROBO2 and NR1H2	roundabout, axon guidance receptor, homolog 2 (Drosophila)	nuclear receptor subfamily 1, group H, member 2	Axon guidance Regulation of Commissural axon pathfinding by Slit and Robo Signaling by Robo receptor	Generic Transcription Pathway Nuclear Receptor transcription pathway		(3-{3-[[2-Chloro-3-(Trifluoromethyl)Benzyl](2,2-Diphenylethyl)Amino]Propoxy}Phenyl)Acetic Acid Benzenesulfonyl N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL
ROBO2 and PPP1R1B	roundabout, axon guidance receptor, homolog 2 (Drosophila)	protein phosphatase 1, regulatory (inhibitor) subunit 1B	Axon guidance Regulation of Commissural axon pathfinding by Slit and Robo Signaling by Robo receptor	Signaling by GPCR Opioid Signalling DARPP-32 events

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