ROBO2 and RDH11

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ROBO2	RDH11
Gene Name		roundabout, axon guidance receptor, homolog 2 (Drosophila)	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cell Surface Integral Component Of Membrane Axolemma Extracellular Vesicular Exosome	Photoreceptor Inner Segment Intracellular Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding	Retinol Dehydrogenase Activity NADP-retinol Dehydrogenase Activity
	Biological Process	Metanephros Development Ureteric Bud Development Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Olfactory Bulb Interneuron Development Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Apoptotic Process Involved In Luteolysis	Retinoid Metabolic Process Phototransduction, Visible Light Adaptation Of Rhodopsin Mediated Signaling Retinol Metabolic Process Retinal Metabolic Process Oxidation-reduction Process
Pathways		Axon guidance Regulation of Commissural axon pathfinding by Slit and Robo Signaling by Robo receptor	Visual phototransduction Signaling by Retinoic Acid The canonical retinoid cycle in rods (twilight vision) Diseases associated with visual transduction RA biosynthesis pathway Retinoid metabolism and transport
Drugs
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000)
Protein-Protein Interactions		16 interactors: BNIP3L CENPU CPE HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TRIM13 UBQLN4	3 interactors: BLOC1S2 CA12 ROBO2
Entrez ID		6092	51109
HPRD ID		11895	09707
Ensembl ID		ENSG00000185008	ENSG00000072042
Uniprot IDs		Q9HCK4	Q8TC12
PDB IDs		1UEM 1UJT 2EDJ
Enriched GO Terms of Interacting Partners?		Roundabout Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Negative Chemotaxis Cell Migration Involved In Sprouting Angiogenesis Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Regulation Of Cytokine-mediated Signaling Pathway Apoptotic Process Involved In Luteolysis Blood Vessel Endothelial Cell Migration Regulation Of Negative Chemotaxis Luteolysis Response To Cortisol Sprouting Angiogenesis Mammary Duct Terminal End Bud Growth Signal Transduction Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cellular Response To Stimulus Olfactory Bulb Interneuron Development Axon Extension Involved In Axon Guidance Signaling Endothelial Cell Migration Cell Communication Chemotaxis Cerebral Cortex Tangential Migration Positive Regulation Of Cell Death Epithelial Cell Migration Epithelium Migration Olfactory Bulb Interneuron Differentiation Response To External Stimulus Axon Guidance Developmental Growth Involved In Morphogenesis Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Chemotaxis Response To Stimulus Apoptotic Process Involved In Development Ameboidal-type Cell Migration Response To Steroid Hormone Regulation Of Cellular Process Regulation Of Protein Metabolic Process Forebrain Neuron Development Substrate-dependent Cell Migration Apoptotic Process Axonogenesis Olfactory Bulb Development Axon Extension Programmed Cell Death Cell Surface Receptor Signaling Pathway Olfactory Lobe Development Cell Death	Negative Regulation Of Negative Chemotaxis Apoptotic Process Involved In Luteolysis Regulation Of Negative Chemotaxis Luteolysis Axon Midline Choice Point Recognition Axon Choice Point Recognition Olfactory Bulb Interneuron Development Chloride Ion Homeostasis Mitochondrial Outer Membrane Permeabilization Platelet Dense Granule Organization Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Olfactory Bulb Interneuron Differentiation Negative Regulation Of Synapse Assembly Positive Regulation Of Mitochondrial Membrane Permeability Anterograde Synaptic Vesicle Transport Microtubule Nucleation Retinal Ganglion Cell Axon Guidance Melanosome Organization Pigment Granule Organization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Microtubule Polymerization Negative Regulation Of Chemotaxis Neuron Projection Development Anterograde Axon Cargo Transport Apoptotic Process Involved In Development Bicarbonate Transport Regulation Of Mitochondrial Membrane Permeability Forebrain Neuron Development Neuron Recognition Regulation Of Membrane Permeability Neuron Development Apoptotic Process Secretory Granule Organization Microtubule Polymerization Or Depolymerization Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Olfactory Bulb Development Programmed Cell Death One-carbon Metabolic Process Olfactory Lobe Development Anion Homeostasis Cell Death Death Axon Cargo Transport Neuron Differentiation Cell Projection Organization Regulation Of Synapse Assembly Cellular Pigmentation Mitochondrial Membrane Organization Forebrain Neuron Differentiation Apoptotic Mitochondrial Changes
Tagcloud ?		arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Difference) ?		arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Intersection) ?