POU3F2 and SOX11 |
POU class 3 homeobox 2 |
SRY (sex determining region Y)-box 11 |
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POU3F2 and POU3F4 |
POU class 3 homeobox 2 |
POU class 3 homeobox 4 |
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POU3F2 and TBP |
POU class 3 homeobox 2 |
TATA box binding protein |
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- RNA Polymerase II Promoter Escape
- RNA Polymerase III Transcription Initiation From Type 3 Promoter
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase I Chain Elongation
- RNA Polymerase II Transcription
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- RNA Polymerase I Transcription Initiation
- RNA Polymerase I Promoter Clearance
- HIV Infection
- RNA Polymerase II Pre-transcription Events
- HIV Life Cycle
- HIV Transcription Initiation
- NoRC negatively regulates rRNA expression
- RNA Polymerase II HIV Promoter Escape
- RNA Polymerase III Transcription Initiation
- RNA Polymerase III Transcription
- RNA Polymerase III Transcription Initiation From Type 1 Promoter
- RNA Polymerase I Transcription
- RNA Polymerase I Transcription Termination
- RNA Polymerase I Promoter Escape
- Epigenetic regulation of gene expression
- Negative epigenetic regulation of rRNA expression
- Late Phase of HIV Life Cycle
- RNA Polymerase III Transcription Initiation From Type 2 Promoter
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- RNA Polymerase III Abortive And Retractive Initiation
- RNA Polymerase II Transcription Initiation
- SIRT1 negatively regulates rRNA Expression
- Transcription of the HIV genome
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PPARD and HDAC4 |
peroxisome proliferator-activated receptor delta |
histone deacetylase 4 |
- Regulation of pyruvate dehydrogenase (PDH) complex
- Pyruvate metabolism
- Fatty acid, triacylglycerol, and ketone body metabolism
- Metabolism of lipids and lipoproteins
- Generic Transcription Pathway
- Signaling by Retinoic Acid
- Import of palmitoyl-CoA into the mitochondrial matrix
- Pyruvate metabolism and Citric Acid (TCA) cycle
- Nuclear Receptor transcription pathway
- The citric acid (TCA) cycle and respiratory electron transport
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
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- Icosapent
- Treprostinil
- Sulindac
- Bezafibrate
- Heptyl-Beta-D-Glucopyranoside
- (11E)-OCTADEC-11-ENOIC ACID
- (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid
- 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid
- 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
- {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid
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PPARG and HDAC4 |
peroxisome proliferator-activated receptor gamma |
histone deacetylase 4 |
- PPARA activates gene expression
- Fatty acid, triacylglycerol, and ketone body metabolism
- Metabolism of lipids and lipoproteins
- Generic Transcription Pathway
- Transcriptional regulation of white adipocyte differentiation
- Nuclear Receptor transcription pathway
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
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- Icosapent
- Troglitazone
- Mesalazine
- Indomethacin
- Rosiglitazone
- Nateglinide
- Sulfasalazine
- Repaglinide
- Telmisartan
- Balsalazide
- Ibuprofen
- Glipizide
- Pioglitazone
- Mitiglinide
- Bezafibrate
- (S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic Acid
- 2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
- (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID
- (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid
- 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
- (4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acid
- (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid
- (8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid
- (8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid
- (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
- difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron
- (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID
- 3-(5-methoxy-1H-indol-3-yl)propanoic acid
- 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
- (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid
- 2-chloro-5-nitro-N-phenylbenzamide
- (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid
- 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid
- 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
- (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid
- 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE
- (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid
- ALEGLITAZAR
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MED1 and CTDP1 |
mediator complex subunit 1 |
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 |
- PPARA activates gene expression
- Organelle biogenesis and maintenance
- Fatty acid, triacylglycerol, and ketone body metabolism
- Metabolism of lipids and lipoproteins
- Nuclear Receptor transcription pathway
- REV-ERBA represses gene expression
- RORA activates circadian gene expression
- Mitochondrial biogenesis
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Generic Transcription Pathway
- Transcriptional regulation of white adipocyte differentiation
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- Activation of gene expression by SREBF (SREBP)
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- Transcriptional activation of mitochondrial biogenesis
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
- Orphan transporters
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- Formation of HIV-1 elongation complex containing HIV-1 Tat
- RNA Polymerase II Transcription
- Abortive elongation of HIV-1 transcript in the absence of Tat
- HIV Infection
- Formation of the Early Elongation Complex
- Tat-mediated elongation of the HIV-1 transcript
- Tat-mediated HIV elongation arrest and recovery
- RNA Polymerase II Pre-transcription Events
- Late Phase of HIV Life Cycle
- Pausing and recovery of Tat-mediated HIV elongation
- Formation of RNA Pol II elongation complex
- HIV elongation arrest and recovery
- HIV Life Cycle
- Pausing and recovery of HIV elongation
- Formation of HIV elongation complex in the absence of HIV Tat
- Formation of the HIV-1 Early Elongation Complex
- HIV Transcription Elongation
- Transcription of the HIV genome
- RNA Polymerase II Transcription Elongation
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MED1 and RORA |
mediator complex subunit 1 |
RAR-related orphan receptor A |
- PPARA activates gene expression
- Organelle biogenesis and maintenance
- Fatty acid, triacylglycerol, and ketone body metabolism
- Metabolism of lipids and lipoproteins
- Nuclear Receptor transcription pathway
- REV-ERBA represses gene expression
- RORA activates circadian gene expression
- Mitochondrial biogenesis
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Generic Transcription Pathway
- Transcriptional regulation of white adipocyte differentiation
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- Activation of gene expression by SREBF (SREBP)
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- Transcriptional activation of mitochondrial biogenesis
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
- Orphan transporters
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- PPARA activates gene expression
- Fatty acid, triacylglycerol, and ketone body metabolism
- Metabolism of lipids and lipoproteins
- Generic Transcription Pathway
- Nuclear Receptor transcription pathway
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- REV-ERBA represses gene expression
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
- RORA activates circadian gene expression
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PPIA and TCF4 |
peptidylprolyl isomerase A (cyclophilin A) |
transcription factor 4 |
- HIV Infection
- Host Interactions of HIV factors
- Integration of provirus
- Platelet degranulation
- Basigin interactions
- Late Phase of HIV Life Cycle
- Cell surface interactions at the vascular wall
- Uncoating of the HIV Virion
- Early Phase of HIV Life Cycle
- Reverse Transcription of HIV RNA
- Assembly Of The HIV Virion
- HIV Life Cycle
- Budding and maturation of HIV virion
- Response to elevated platelet cytosolic Ca2+
- Minus-strand DNA synthesis
- Platelet activation, signaling and aggregation
- Binding and entry of HIV virion
- Plus-strand DNA synthesis
- APOBEC3G mediated resistance to HIV-1 infection
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- CDO in myogenesis
- Myogenesis
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- Cyclosporine
- L-Proline
- (3r)-1-Acetyl-3-Methylpiperidine
- Ethyl Oxo(Piperidin-1-Yl)Acetate
- (3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl-
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PPP1CA and MAP4K4 |
protein phosphatase 1, catalytic subunit, alpha isozyme |
mitogen-activated protein kinase kinase kinase kinase 4 |
- Loss of Function of TGFBR2 in Cancer
- Signaling by GPCR
- TGFBR2 MSI Frameshift Mutants in Cancer
- Metabolism of lipids and lipoproteins
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- Opioid Signalling
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- Downregulation of TGF-beta receptor signaling
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- Lipid digestion, mobilization, and transport
- TGF-beta receptor signaling activates SMADs
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- DARPP-32 events
- SMAD4 MH2 Domain Mutants in Cancer
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- Oxidative Stress Induced Senescence
- Cellular Senescence
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PPP1CA and SLC45A1 |
protein phosphatase 1, catalytic subunit, alpha isozyme |
solute carrier family 45, member 1 |
- Loss of Function of TGFBR2 in Cancer
- Signaling by GPCR
- TGFBR2 MSI Frameshift Mutants in Cancer
- Metabolism of lipids and lipoproteins
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- Opioid Signalling
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- Downregulation of TGF-beta receptor signaling
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- Lipid digestion, mobilization, and transport
- TGF-beta receptor signaling activates SMADs
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- DARPP-32 events
- SMAD4 MH2 Domain Mutants in Cancer
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PPP1CC and MAP4K4 |
protein phosphatase 1, catalytic subunit, gamma isozyme |
mitogen-activated protein kinase kinase kinase kinase 4 |
- Loss of Function of TGFBR2 in Cancer
- Mitotic Prometaphase
- Metabolism of lipids and lipoproteins
- Separation of Sister Chromatids
- Downregulation of TGF-beta receptor signaling
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGF-beta receptor signaling activates SMADs
- Mitotic Anaphase
- TGFBR1 LBD Mutants in Cancer
- M Phase
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- Lipid digestion, mobilization, and transport
- Cell Cycle, Mitotic
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- Resolution of Sister Chromatid Cohesion
- Mitotic Metaphase and Anaphase
- SMAD4 MH2 Domain Mutants in Cancer
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- Oxidative Stress Induced Senescence
- Cellular Senescence
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- 9,10-Deepithio-9,10-Didehydroacanthifolicin
- Calyculin A
- (2S,5R,8S,11R,12S,15S,18S,19S,E)-8-ISOBUTYL-18-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,2,5,12,15,19-HEXAMETHYL-3,6,9,13,16,20,25-HEPTAOXO-1,4,7,10,14,17,21-HEPTAAZACYCLOPENTACOS-21-ENE-11,22-DICARBOXYLIC ACID
- Motuporin
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PPP1CC and ZDBF2 |
protein phosphatase 1, catalytic subunit, gamma isozyme |
zinc finger, DBF-type containing 2 |
- Loss of Function of TGFBR2 in Cancer
- Mitotic Prometaphase
- Metabolism of lipids and lipoproteins
- Separation of Sister Chromatids
- Downregulation of TGF-beta receptor signaling
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGF-beta receptor signaling activates SMADs
- Mitotic Anaphase
- TGFBR1 LBD Mutants in Cancer
- M Phase
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- Lipid digestion, mobilization, and transport
- Cell Cycle, Mitotic
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- Resolution of Sister Chromatid Cohesion
- Mitotic Metaphase and Anaphase
- SMAD4 MH2 Domain Mutants in Cancer
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- 9,10-Deepithio-9,10-Didehydroacanthifolicin
- Calyculin A
- (2S,5R,8S,11R,12S,15S,18S,19S,E)-8-ISOBUTYL-18-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,2,5,12,15,19-HEXAMETHYL-3,6,9,13,16,20,25-HEPTAOXO-1,4,7,10,14,17,21-HEPTAAZACYCLOPENTACOS-21-ENE-11,22-DICARBOXYLIC ACID
- Motuporin
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PPP2R2B and CHEK2 |
protein phosphatase 2, regulatory subunit B, beta |
checkpoint kinase 2 |
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PPP2R2B and KLHL15 |
protein phosphatase 2, regulatory subunit B, beta |
kelch-like family member 15 |
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PPP2R2B and TP53 |
protein phosphatase 2, regulatory subunit B, beta |
tumor protein p53 |
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- Cellular Senescence
- Activation of BH3-only proteins
- p53-Dependent G1/S DNA damage checkpoint
- Oncogene Induced Senescence
- p53-Dependent G1 DNA Damage Response
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- Pre-NOTCH Transcription and Translation
- Stabilization of p53
- Transcriptional activation of p53 responsive genes
- Programmed Cell Death
- Pre-NOTCH Expression and Processing
- G1/S DNA Damage Checkpoints
- Intrinsic Pathway for Apoptosis
- Transcriptional activation of cell cycle inhibitor p21
- DNA Damage/Telomere Stress Induced Senescence
- Signaling by NOTCH
- Factors involved in megakaryocyte development and platelet production
- Activation of NOXA and translocation to mitochondria
- Oxidative Stress Induced Senescence
- Autodegradation of the E3 ubiquitin ligase COP1
- Activation of PUMA and translocation to mitochondria
- Cell Cycle Checkpoints
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PPP2R2B and TOP1 |
protein phosphatase 2, regulatory subunit B, beta |
topoisomerase (DNA) I |
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- Irinotecan
- Topotecan
- Camptothecin
- Lucanthone
- Sodium stibogluconate
- 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM
- 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE
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PPP2R2B and RAC1 |
protein phosphatase 2, regulatory subunit B, beta |
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
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- Signaling by GPCR
- DCC mediated attractive signaling
- FCERI mediated MAPK activation
- Signaling by Wnt
- Nef and signal transduction
- Signaling by SCF-KIT
- DAP12 signaling
- EPH-Ephrin signaling
- Fcgamma receptor (FCGR) dependent phagocytosis
- Regulation of actin dynamics for phagocytic cup formation
- Sema4D induced cell migration and growth-cone collapse
- DAP12 interactions
- Host Interactions of HIV factors
- CD28 co-stimulation
- The role of Nef in HIV-1 replication and disease pathogenesis
- Factors involved in megakaryocyte development and platelet production
- GPCR downstream signaling
- Signaling by VEGF
- Fc epsilon receptor (FCERI) signaling
- Sema3A PAK dependent Axon repulsion
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- Platelet activation, signaling and aggregation
- PCP/CE pathway
- Adaptive Immune System
- Axon guidance
- Costimulation by the CD28 family
- HIV Infection
- Translocation of GLUT4 to the plasma membrane
- L1CAM interactions
- VEGFA-VEGFR2 Pathway
- EPHB-mediated forward signaling
- Inactivation of Cdc42 and Rac
- Ephrin signaling
- EPH-ephrin mediated repulsion of cells
- Activation of Rac
- VEGFR2 mediated vascular permeability
- Sema4D mediated inhibition of cell attachment and migration
- G alpha (12/13) signalling events
- Sema4D in semaphorin signaling
- Netrin-1 signaling
- Innate Immune System
- Signalling by NGF
- Signal transduction by L1
- Cell death signalling via NRAGE, NRIF and NADE
- Semaphorin interactions
- p75 NTR receptor-mediated signalling
- beta-catenin independent WNT signaling
- CD28 dependent Vav1 pathway
- DSCAM interactions
- NRAGE signals death through JNK
- GPVI-mediated activation cascade
- Signaling by Robo receptor
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- Guanosine-5\'-Diphosphate
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PPP2R4 and HDAC4 |
protein phosphatase 2A activator, regulatory subunit 4 |
histone deacetylase 4 |
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
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PPP5C and DISC1 |
protein phosphatase 5, catalytic subunit |
disrupted in schizophrenia 1 |
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SRGN and BAG6 |
serglycin |
BCL2-associated athanogene 6 |
- Response to elevated platelet cytosolic Ca2+
- Platelet degranulation
- Platelet activation, signaling and aggregation
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